USA-Scientist I (Scientific) - TalentBurst

Industry: Biotechnology
Title: Scientist I
Job ID: SNFIJP00009323
Location: Cambridge, MA
Duration: 12 months contract (+Chances of extension)

Summary:
*** is seeking a highly motivated Scientist I or Scientist II to join the Non-Viral Gene Therapy (NVGT) Team. The successful candidate will have hands-on experience in antibody and protein engineering, with a focus on bioconjugation chemistry. The candidate will work closely with the LNP formulation team to achieve extrahepatic delivery of LNPs.

Responsibilities:

Execute protein conjugation reactions for both screening efforts and developability to enable nanoparticle targeting to specific cells and/or tissues.

Perform downstream analytical assays such as SDS-PAGE, SEC-HPLC, RP-HPLC, BLI, DSF, CE-SDS and/or flow-cytometry.

Perform incorporation of targeting antibody into LNPs and execute associated analytical assays, including DLS, zeta potential, nucleic acid content, endotoxin

Design protein and antibody molecules at the primary sequence level

Support management of CRO for molecule production

Closely work with therapeutic area biologists and project teams to design functional experiments and interpret data

Execute and carefully document experiments using electronic laboratory notebook system and clearly communicate results to team members.

Plan, execute, and record experiments as guided in a time sensitive manner.

Assume responsibility for critical reagent sourcing and maintain adequate supply and inventory.

Author standard operating procedures, study plans and reports and present findings.

Foster creativity, productivity, execution with a sense of urgency, scientific integrity and accountability. Maintains a collaborative culture.

Requirements:

PhD in Chemistry, Biology, Biological Engineering, or a related field with a minimum of 1-3 years of relevant industry experience.

Strong experience with protein and antibody engineering workflows, including primary sequence design, expression, purification, characterization

Direct experience with site-specific bioconjugate chemistry

Strong analytical biochemistry experience for protein and antibody engineering

Proficient in performing structure-function analysis and bioinformatic analysis of antibodies, antigens, and other proteins

Experience with automation and high throughput platform(s)

Experience with Biolayer Interferometry or equivalent technique

Preferred use of computational and AI/ML approaches for rational protein engineering, including AI 3D structure prediction, homology modeling, antibody/antigen docking, other relevant experience

Preferred familiarity with formulation and analysis of lipid nanoparticles for research use

Outstanding written and oral communication skills along with the ability to work collaboratively in a team setting.

Demonstrated knowledge and skills in solving scientific problems, ability to troubleshoot, and willingness to learn.

Demonstrated ability to independently design, execute, interpret, and present experimental results.

Flexibility to adapt to rapidly changing priorities and deadlines in a dynamic, fast paced industry and work environment.


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