Sr. Scientist II, In Vivo Therapeutics Discovery - Editas Medicine

At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.

We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.

Together, we are leading the way towards a healthier and more equitable future.

Editas Medicine is seeking a highly motivated and collaborative cell biologist to join our In Vivo Therapeutics Discovery group. In this role, you will support on-going efforts to develop in vivo gene editing therapies and contribute to the evaluation and identification of new targets. You will lead the development and characterization of rodent animal models and molecular and cell-based assays to evaluate the extent and effects of gene editing. The ideal candidate will have a diverse in vitro and in vivo experimental skill set with a strong background in primary cell culture and molecular biology, a track record of creative thinking, and a deep interest in genome editing. The successful candidate will be part of a dynamic, multidisciplinary discovery team dedicated to the development of gene editing-based therapies for major disease indications.

Key Responsibilities & Accountabilities:

• Serve as subject matter expert and lead early-stage discovery programs through DC nomination.
• Lead assay development and implementation to demonstrate gene editing and impact on target expression in relevant cells in vitro and target tissues in vivo.
• Plan and execute mouse experiments to understand in vivo therapeutic activity, efficacy, and PK/PD properties associated with drug candidates.
• Perform in vitro or ex vivo assays to assess disease phenotype.
• Contribute to the exploration and identification of new targets and engage with cross-functional stakeholders to determine the probability of technical, clinical, and commercial success.
• Contribute to timeline, milestones, success criteria, MPP, and TPP development.
• Generate technical documents, SOPs, study reports and other forms of documentation for IND-enabling activities and procedure development.
• Suggest and implement changes to IACUC protocols.
• Synthesize literature, analyze and present data within and outside the organization.
• Serve as a technical and scientific resource for junior staff.
• Share responsibility in maintaining lab equipment and reagent inventory.
• Maintain electronic lab notebook in a timely fashion.
• Interact with vendors, collaborators, and internal teams for various functions.

Requirements

Knowledge, Skills & Capabilities:

• Subject matter expertise in disease(s) of peripheral indication space as demonstrated by publications and/or track record.
• Expertise in mammalian cell culture, including primary cells, the development of cell-based assays, and molecular biology techniques.
• Must have hands on experience working with mouse models and be proficient in dosing and tissue harvesting.
• Proven track record of collaborating with cross-functional teams and ability to thrive in matrixed environment.
• Demonstrated capability of innovating approaches to drive programs forward.
• Attention to detail and ability to conduct high-quality research and execute research plans in a timely and organized manner.
• Comfortable working in a fast-paced environment and able to adjust quickly to changing priorities.
• Outstanding communication skills, both written and oral, and an ability to work in a team-oriented, multidisciplinary environment.
• Experience mentoring research associates.
• Experience with gene editing technologies and lipid nanoparticle delivery is highly desired.
• Track record of advancing early-stage discovery programs through DC nomination desired.

Education & Relevant Work Experience

• PhD in cell and molecular biology with 8 – 10 years of research experience, ≥5 years in an industry setting.

Benefits

Benefits Summary:

Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

If you are a results-focused and collaborative professional with a passion for advancing transformative therapies, we invite you to apply. Join us at the forefront of genetic innovation and be a key contributor to Editas Medicine's mission of redefining healthcare through cutting-edge genetic technologies.

Fostering Belonging. Fueling Innovation. Transforming Lives.