Sr. Research Associate, in vitro Biology at Firefly Bio

About Firefly Bio:

Firefly specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders. Our mission is to unlock the full potential of bioconjugates and develop medicines with long-lasting benefits for patients. We are establishing an expert team to build state-of-the-art platform capabilities for the invention and development of innovative drug conjugates. Our company culture is built on the values of Focus, Integrity, Respect and Energy. We are looking for passionate individuals committed to making an impact on the future of medicine.

We are seeking a highly motivated Sr. Research Associate to join our in vitro biology team with a focus on oncology. The selected candidate will be responsible for evaluating novel ADC (antibody drug conjugate) based oncology therapeutics in cell-based assays and screening. Hands-on experience and knowledge with cell-based screening and assay development related to oncology is required. The successful candidate will be responsible for executing and communicating data to support the progression of our oncology focused programs. Title and compensation will be commensurate with experience.

Primary Responsibilities:

• Plan and perform cell-based assays to interrogate effects of degraders and inhibitors on signaling pathways and cellular viability
• Maintain cultures of multiple human cancer cell lines simultaneously to support experimental efforts
• Apply various genetic, molecular and cellular techniques to develop mechanistic understanding of novel degrader antibody conjugates
• Execute microplate-based quantitative assays
• Analyze and interpret experimental data and present results at internal meetings
• Collaborate with team members to generate novel insights into key oncogenic drivers
• Interface with cross-functional project team members, and participate in and present at project team meetings and cross-departmental team meetings

Qualifications & Prior Experience required:

• BS/MS in Cell/Molecular Biology, Biology, Genetics, Biochemistry, or related field

• 4 years working in industry in a research or drug development setting involving cell/tissue culture and cell/molecular biology, ideally in the assay development space

• Demonstrated proficiency with a wide range of cell and molecular biology techniques (e.g., cell line engineering, SDS-PAGE/Western blot, qPCR, etc.)
• Proficiency with cell culture, including the ability to maintain multiple human cancer cell lines simultaneously with strong aseptic technique
• Ability to execute plate-based experiments with various readouts, i.e. ELISA, MSD, luminescence, fluorescence, TR-FRET, AlphaLISA, fluorescence live-cell imaging (IncuCyte).
• Analysis of concentration-response curves and scientific data analysis software
• Demonstrated ability to multi-task, prioritize, and complete tasks efficiently to meet project deadlines
• Proven ability to proactively and independently problem solve with minimum guidance
• Highly organized, with proven record keeping and excellent written/verbal communication skills to effectively communicate research findings
• Innovative and adaptable team-player with an eagerness to learn new techniques
• A positive, can-do mindset with the ability to work independently and collaboratively within a team environment
• Requires the ability to work onsite five days a week

Benefits

Every team member is essential in shaping Firefly Bio’s culture and science and for our success. We offer competitive compensation packages including stock options and the opportunity to be part of ground-breaking research. Firefly Bio is an equal opportunity employer and will consider all applicants for employment. Firefly Bio does not discriminate based on race, sex, color, religion, age, national origin, marital status, disability, veteran status, genetic information, sexual orientation, gender identity or any other reason prohibited by law in provision of employment opportunities and benefits.