Senior Scientist, Pharmacokinetics & Drug Metabolism - Mass Spectrometry at Amgen

HOW MIGHT YOU DEFY IMAGINATION?

Youve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

Senior Scientist Mass Spectrometry Pharmacokinetics & Drug Metabolism

What you will do

Lets do this. Lets change the world. In this role, you will be a part of the department of pharmacokinetics and drug metabolism (PKDM) within Amgen Research. This group is dedicated to the discovery and development of novel, effective, and safe medicines. The successful candidate will work in a team environment to characterize the absorption, distribution, metabolism, excretion, and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with subject areas such as medicinal chemistry, protein sciences, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to craft promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation, and contribute to IND and NDA filing

• Develop and perform quantitative LCMS assays for various molecular modalities.
• Explore new and novel analytical technologies to support the development of novel and unique modalities within Amgen pipeline.
• Develop targeted and untargeted proteomics approaches to support studies such as protein-drug adduct identification, target occupancy determination, etc.
• Employ bioanalytical techniques to support the biotransformation of large molecules.
• Be able to troubleshoot independently when instrument or assay problems arise.

Other responsibilities will include basic biochemistry research, electronic laboratory notebook keeping and communication of results to project teams.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The PKDM scientific professional we seek has these qualifications.

• Doctorate degree in Analytical Chemistry or a related discipline with strong LCMS and/or CEMS training
• Masters degree and 4 years of the relevant experience or
• Bachelors degree and 6 years of the relevant experience

• Proven expertise and experience in LCMS and/or CEMS are required.
• Demonstrated track record of successfully developing LCMS or CEMS methods.
• Hands on experience in sample preparation technique (biological processing, tissue homogenization, immunoaffinity capture, enzymatic digestion, SPE etc.) and experience with automated platform (AssayMAP Bravo, Tecan etc.) is not required but preferred.
• Hands on experience in various HPLC, CE, and Mass Spec instruments is preferred, such as high-flow LC, micro-flow LC, nanoflow LC, QQQ, ToF, Orbitrap, etc.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans and bi-annual company-wide shutdowns
• Flexible work models, including remote work arrangements, where possible

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.