Senior Scientist, Organic Synthetic Chemistry - Stealth Mode Biotech Company

A newly created company is seeking an experienced Synthetic Organic Chemist to support a revolutionary chemistry AI platform for small molecule therapeutic discovery from lead identification to lead candidate on behalf of clients. 

Key Responsibilities

• In collaboration with cross functional teams (automation engineers, analytical, biology and AI/ML) drive solutions for the development of reaction conditions for the automated synthesis of small molecules.
• Develop, troubleshoot, and optimize synthetic routes for rapid generation of complex building blocks.
• Develop and optimize organic reactions, work-up and SPE purification for automation in HTS fashion.
• Optimize and test conditions to clean up synthesized compounds on solid phase support, including metal scavenging, as well as develop LC conditions for final product purification.
• Help design and test protocols for automation system validations.
• Support continuous automated synthesis of small molecules on HTS fashion.
• Identify and design synthetic routes for complex building blocks. Guide, troubleshoot and oversee CROs on the synthesis of the compounds, as applicable.
• Support analytical chemists on chromatographic methods development and analytical equipment troubleshooting.
• Establish and maintain synthetic chemistry project timeline, and partner with functional leads to coordinate and drive activities.
• Help drive cross-functional communication and decision-making, ensuring alignment with internal and external stakeholders.
• Communicate project status and issues to the management and other stakeholders through meetings and key documents.

Qualifications 

• PhD degree in Organic Chemistry or related fields with at least 5 years of pharmaceutical industry experience. Candidates with a mixed combination of degrees, and longer industry experience may be considered. Medicinal / Synthetic organic chemist is preferred.
• Demonstrated strong hands-on background on route scouting for drug candidates’ synthesis.
• Well versed in metal-catalyzed organic reactions is a must. High throughput screening expertise is desired.
• Demonstrated ability for taking initiative, creativity, and innovation in problem solving.
• Attention to detail and proactive with excellent follow through.
• Ability to work both independently and together with the analytical, automation and biology teams.
• Strong ability to deliver complex objectives under aggressive timelines in a rapidly changing environment.
• Ability to consistently generate quality data and manage large databases.
• Well versed in analytical technology such as LC (including prep and semi-prep), NMR, LC-MS, KF, etc. SFC knowledge is a plus.
• Knowledge on design of experiments (DoE) is ideal.
• Proficient in purification by column chromatography (manual and automated, such as Biotage or equivalent.
• Automation and AI/ML knowledge is a plus.

This stealth mode company provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

Location: New York, NY

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Expected Salary Range: $145,000 - $174,500 (Compensation will be commensurate with experience and expertise.)

In addition to competitive salaries, we offers a comprehensive benefits package.