Senior Scientist I/II, Bioinformatics - Dren Bio

Senior Scientist I/II, Bioinformatics

About the Company:

Dren Bio (the "Company") is a privately held, clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company's management team and scientific advisors have profound expertise covering the discovery and development of specially engineered antibodies. Dren Bio's pipeline encompasses a multitude of programs from its two distinct, wholly-owned technologies. The Company's lead development candidate, DR-01, induces antibody-mediated killing of a specific cell type known to play a key role in various hematologic malignancies and autoimmune disorders. In addition to DR-01, the Company has launched multiple programs from its proprietary Targeted Myeloid Engager and Phagocytosis Platform, a bispecific antibody-based technology that offers a novel mechanism of action focused on selectively engaging myeloid cells (antigen presenting cells) for the targeted depletion of pathologic cells and other disease-causing agents.

Function:

Immunology Research

Level:

Senior Scientist I/II

Location:

Foster City, CA

Reporting Manager:

Director, Immunology

About the Opportunity:

As a key member of the team, you will focus on autoimmunity and cancer, collaborating closely with experimental scientists in the Immunology group. Your primary role will be to design and analyze multi-omic experiments using pre-clinical models and patient samples, with the aim of generating critical insights into the biology and progression of autoimmunity and cancer. These insights will guide the discovery of novel therapeutic targets and biomarkers and address essential questions in both forward and reverse translational research.

Role and Responsibilities:

• Performs analysis of preclinical and clinical metadata and multi-modal omics data,including but not limited to: scRNA-seq, bulk RNA seq, CITE-seq, flow cytometry, andproteomics

• Independently identifies and analyzes disease-relevant external datasets to generatenew hypotheses to support internal programs

• Independently performs rigorous and reproducible data analysis of complex internaland external genomics datasets (e.g. TCGA), adapting approaches & methodology asneeded based on project goals.

• Generates publication quality figures from multiomics analyses for internal andexternal publications

• Meets production deadlines for data analysis and is able to pivot between multipleprojects

• Builds out our internal computational platform to allow scalable analysis andintegration with automation

• Owns the data workflow for some of our lead therapeutic programs by contributing toexperimental design, primary analysis, and generating and communicating insights

Education, Experience and Qualification Requirements:

• Ph.D. in Computational Biology, Biostatistics, Bioinformatics, or similar with astrong publication record

• Alternatively Ph.D. in Immunology, Molecular Biology combined with a record ofhigh-throughput data analysis, supported by publication

Core Competencies, Knowledge and Skill Requirements:

• Solid understanding of the relevant concepts in immunology, immuno-oncology, andenthusiasm for learning more.

• Broad experience with data generated by one or more high-throughput molecular assays:Next-generation sequencing, flow cytometry, etc.

• Strong experience in the use of a high-level programming language such as Python or Rfor complex data analysis

• Understanding of the statistical principles behind current best practices inhigh-throughput molecular data analysis

• Track-record of high-profile scientific publications

• Strong quantitative reasoning, statistical analysis, and data visualization skills,with a demonstrated ability to apply them to scientific problems

• Excellent written and verbal communication skills as demonstrated by successfulcollaborations between wet and dry scientific teams

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. The base pay range for this position at commencement of employment is expected to be between $144,000 and $184,000 per year. At Dren Bio, pay ranges are determined by role, level(s), and location. The range displayed in this job posting reflects the minimum and maximum new hire pay for candidates located across all United States job markets. Within the range, individual pay will be determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, Dren Bio’s Human Resources department can share more about the specific pay range based on the market location of the candidate.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.