Senior Research Associate/Associate Scientist - Evercrisp Biosciences

Evercrisp Biosciences, founded by world-renowned scientists who bring expertise and proprietary technology to the company, is currently operating in stealth mode with a substantial Series A commitment from Apple Tree Partners (ATP) to take the company from discovery to proof of concept. Evercrisp is initially focused on high-confidence, genetically validated but “difficult to drug” targets in areas of high unmet need where genome editing can make a significant difference. At Evercrisp, innovation, collaboration, and commitment to making a significant impact on human health guide our work.

Position Summary:

We are seeking an exceptional and detail-oriented Senior Research Associate/Associate Scientist to join our Protein Sciences team.  In this role, you will play a critical part in our protein engineering efforts by generating high-quality proteins to support downstream in vitro and in vivo experiments. The ideal candidate will excel in a fast-paced environment and contribute directly to shaping Evercrisp's scientific advancements.

Key Responsibilities:

• Express and purify recombinant proteins at small and large scale to support preclinical development of therapeutic proteins.
• Characterize proteins using established quality control (QC) workflows to ensure suitability for downstream applications.
• Troubleshoot and resolve challenges in protein purification and characterization processes.
• Maintain accurate protein inventory by registering and managing data in internal databases.
• Present results, interpret experimental data, and provide actionable insights during team meetings.
• Document experiments comprehensively and accurately in an electronic lab notebook (ELN).
• Communicate effectively in both oral and written formats to convey results and progress.

Qualifications

Education:

Bachelor's degree with 3+ years of industry experience or Master's degree in Biology, Biochemistry, or a related scientific field.

Technical Experience:

• At least 2 years of hands-on experience in protein purification and characterization.
• Proficiency with various expression systems, including bacterial and mammalian platforms.
• Expertise in protein purification techniques such as affinity capture, ion exchange, and size exclusion chromatography.
• Experience operating FPLC systems (e.g., AKTA, Bio-Rad NGC).
• Strong background in protein characterization methods, including SDS-PAGE and analytical SEC.
• Experience producing low-endotoxin proteins for in vivo studies.
• Knowledge of advanced protein characterization methods (e.g., DLS, ELISA, BLI) is a plus.
• Familiarity with medium or high-throughput expression and purification workflows is advantageous.

Skills and Attributes:

• Strong attention to detail, accurate record-keeping, and adherence to lab best practices.
• Ability to develop methods, optimize protocols, and draft technical documentation.
• A creative and problem-solving mindset, with the ability to prioritize tasks across multiple projects.
• Thrives in a dynamic, collaborative, and fast-paced team environment.

What We Offer:

At Evercrisp Biosciences, you'll be part of a passionate team working at the forefront of genetic medicine. We offer a competitive compensation package, comprehensive benefits, and the opportunity to grow professionally in a highly innovative environment.

At Evercrisp, we value diversity, encourage professional growth, and provide competitive benefits and compensation. Evercrisp is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.