Senior/Principal Scientist, Pharmaceutical Development at Nurix Therapeutics

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position Description

Nurix is seeking a Senior/Principal Scientist, Pharmaceutical Development to provide scientific, technical, and hands-on leadership of small molecule oral solid formulation development for pre-clinical through Phase 1 clinical trial stages. Responsibilities will include but are not limited to:

• Lead small molecule preclinical and clinical formulation development and characterization in support of internal Nurix development programs
• Manage outsourced development projects and manufacturing including timeline and resource planning, to ensure milestones and deliverables are met efficiently
• Partner with Nurix Chemical Development and Analytical Development to identify optimal drug substance properties and control strategies
• Oversee preparation and characterization of pre-clinical drug products for in-house and partner with Global Supply Chain Operations for outsourced studies and clinical manufacturing
• Serve as drug product SME for cross-functional project teams
• Author and review relevant sections of regulatory filings, technical protocols, reports, ect.
• Manage and mentor research associates
• Contribute to internal and external presentations and publications.

Required Qualifications

• In-depth knowledge and demonstrated expertise and accomplishment in oral solid dose form, characterization, manufacturing process development, and Phase I clinical manufacturing
• Significant experience with design, scale-up, and outsourced manufacture of amorphous solid dispersion-based formulations design (spray drying, hot melt extrusion, tableting and encapsulation); experience with other enabled oral formulations a plus
• Prior experience in formulation of targeted protein degrader molecules (aka CTMs, degraders, PROTACS) a plus
• Thorough understanding of analytical techniques used for pre-formulation and characterization of oral solid dose forms including HPLC, LC-MS, XRPD, DSC, Dissolution, and KF
• Excellent technical problem solving and troubleshooting abilities
• Excellent written and oral communications skills
• PhD (preferred) or MS in chemistry, pharmaceutics, engineering, or related field with at least 7 years relevant industrial experience
• Ability to travel up to 25% of time

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