Senior Manager Manufacturing - Downstream Purification Operations at Amgen

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At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Manager Manufacturing - Downstream Purification Operations

What you will do

Lets do this. Lets change the world. In this vital role you will provide strategic oversight for all four shifts within the highly technical and complex downstream (purification) area, including operations associated with I-530. This position is critical to the advancement of AR30s capabilities and capacity as we continue to scale up production and enable innovation within Amgens manufacturing network.

The Senior Manager will oversee the purification operations tied to I-530, a transformative model that integrates production scalability and efficiency from both AR5 and AR30 plants. This includes driving the implementation of process enhancements and new product introductions, while also addressing capacity challenges through innovative resource and capacity management solutions. I-530s integration has unlocked significant manufacturing efficiencies, enabling multi-scale production and rapid adaptability to meet growing demands.

Key Responsibilities:

• Safety and Quality Oversight: Ensure safety and quality standards are upheld for the purification of biologics and associated processes in AR30 manufacturing, including I-530 operations.

• Operational Leadership: Lead downstream purification teams to reliably deliver production targets, increase run rates, and meet yield goals while ensuring compliance with GMP regulations.

• I-530 Operations Leadership: Oversee I-530 purification activities, leveraging its capability to optimize manufacturing scalability across AR30 and AR5. Drive alignment on capacity utilization and resource deployment for increased efficiency.

• Talent Development: Mentor and develop frontline managers and staff, fostering an environment of continuous learning and operational excellence.

• Innovation and Process Enhancement: Drive process transformation initiatives to support higher efficiency and eliminate non-value-added activities. Lead operational readiness for process enhancements, including innovative changeover and scheduling solutions.

• Network Collaboration: Collaborate cross-functionally with F&E, PD, Quality, EHSS, QC, and other stakeholders to ensure alignment on strategic objectives and key milestones.

• Capacity and Financial Planning: Perform resource planning, financial assessments, and capacity modeling, ensuring downstream purification can meet the evolving needs of the long-range manufacturing plan.

• Continuous Improvement: Lead initiatives to reduce deviations, improve success rates, and maintain high adherence to disposition timelines. Champion the adoption of innovative tools such as digital control solutions and real-time operational oversight platforms.

• Agile Workforce Leadership: Implement AR30s Agile Workforce model by enabling cross-training, dynamic resource allocation, and flexible staffing practices to enhance responsiveness and productivity.

• Sustainability Leadership: Contribute to achieving AR30s sustainability goals through process optimizations that reduce waste and energy consumption.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a collaborative partner with these qualifications.

Basic Qualifications:

• High school diploma / GED and 12 years of Manufacturing & Operations experience OR

• Associates degree and 10 years of Manufacturing & Operations experience OR

• Bachelors degree and 8 years of Manufacturing & Operations experience OR

• Masters degree and 6 years of Manufacturing & Operations experience OR

• Doctorate degree and 2 years of Manufacturing & Operations experience

In addition to meeting at least one of the above requirements, you must have a minimum of 2 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources. Your managerial experience may run concurrently with the required technical experience referenced above

Preferred Qualifications:

• Proven leadership experience in manufacturing, particularly in biologics downstream purification or single-use manufacturing environments.

• Demonstrated ability to lead operational excellence initiatives and cross-functional collaborations.

• Strong technical acumen in biologics purification processes, with experience in process optimization and scale-up operations.

• - Skilled in change management, team building, and fostering innovation.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans

• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now

for a career that defies imagination

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Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.