Senior Director, Cardiovascular Clinical Development - CRISPR Therapeutics

Company Overview

CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom.

Position Summary

We’re seeking a Senior Medical Director with a high degree of scientific acumen who is motivated by the unique opportunity to bring innovative therapies to market. In this role, the incumbent will help develop CRISPR’s cardio-vascular (CV) programs in various indications. The successful candidate will work across several functional teams, support the Clinical Development function and be responsible for tactical implementation of clinical studies for the lead CV programs.  This will include providing direct medical oversight for proof of concept and pivotal clinical trials, and clinician’s input into all aspects of discovery, preclinical development, regulatory and commercial strategies.

This is a highly visible position as the company progresses a pipeline of innovative therapies to address serious cardiovascular and metabolic unmet medical needs.

Responsibilities

• Contribute to the development of robust clinical development plans for the CV programs
• Develop protocols and oversee clinical trials as a medical monitor
• Develop in-depth knowledge of the underlying scientific principles of the diseases studied and the application of gene therapies
• Collaborate with Clinical Development partners and across functions to ensure program success 
• Contribute to the development of regulatory strategy and act as the medical expert in meetings with regulatory authorities
• Identify and establish relationships with leading key opinion leaders (KOLs) and principal investigators
• Organize and present at relevant clinical advisory boards and medical/scientific meetings
• Serve as the Sponsor’s medical representative to external collaborators for assigned projects
• Travel, as needed, nationally and internationally

Minimum Qualifications

• A medical degree (MD), and minimum of 3 years Pharmaceutical/Biotech industry experience, including time managing clinical trials, or a minimum of 5 years in a related, research/academic environment. Background in CV medicine is required.
• Strong scientific background with experience in reviewing and interpreting scientific and study data.
• Medical monitor experience in clinical development, or clinical translational medicine related areas.
• Working knowledge of biostatistics, data management, clinical operations, and scientific and technical processes desirable.
• Experience in building and maintaining effective relationships with external KOLs, advisory boards and other key external therapeutic area influencers desirable.
• Team player who works collaboratively in a team matrix environment.
• Ability to work independently to resolve challenges and conflicts.
• Excellent written and oral communication skills.
• Integrity and highest ethical standards and a sense of personal accountability.
• Quickly adapt and provide innovative solutions to challenges as they present themselves.

Preferred Qualifications

• Prior Clinical Development experience working for a leading biotechnology company

Competencies

• Collaborative – Openness, One Team
• Undaunted – Fearless, Can-do attitude
• Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
• Entrepreneurial Spirit – Proactive. Ownership mindset.

CRISPR Therapeutics believes in fostering a dynamic workplace that balances remote work flexibility with the benefits of in-person interactions. Our employees work at least three days on-site, creating a collaborative work environment, where we cultivate mentorship opportunities, increase cross-functional communication and offer opportunities for our employees to connect. Certain lab based and manufacturing positions are located fully on-site.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

To view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy