Scientist/Sr. Scientist, Lead Discovery - General Proximity

tl;dr

General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking first-rate lead discovery scientists to help us pioneer this uncharted frontier of drug discovery.

Our Story

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our technology holds the same promise.

The Position

We are seeking an experienced Lead Discovery Scientist to be a member of our Platform/Drug Discovery Team. In this position, you will work in close conjunction with our Biology Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Your responsibilities will include leading the design and execution of lead discovery campaigns to identify novel small molecule hits and advance them through hit-to-lead and lead optimization stages, working with the Platform and Biology teams to develop and implement biochemical and cell-based assays for hit identification and lead optimization, evaluating compound potency, selectivity, and mechanism of action, biophysical and biochemical assay development, and expressing, purifying, and characterizing target proteins for structural studies.

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

• PhD in Biochemistry, Biophysics, Structural Biology, or a related field.
• Proficiency in: 
  • Strong expertise in the design and execution of lead discovery campaigns using HTS techniques such as DEL and SMM 
  • Strong expertise in phenotypic cell-based assay development 
  • Experience in biochemical and biophysical assay development (e.g., SPR, BLI, DSF, etc.) 
  • Experience in PPI techniques (e.g., BRET, APEX/BioID, AlphaScreen) 
  • Mammalian cell culture, molecular biology/cloning, PCR, and other common biology techniques like western blotting, flow cytometry, microscopy 
  • Familiarity with automatic, robotic dispensers, liquid handlers 
  • Strong problem-solving skills and the ability to work independently as well as part of a team 
  • Strong written and oral communication skills 

• Nice to have:
  • 2+ years of post-degree experience 
  • Familiarity or experience with PROTAC/next-gen IPM technologies 
  • Experience in computational drug discovery
  • Experience in protein expression, purification, and structural characterization techniques such as X-ray crystallography, cryo-EM, and computational modeling 
  • Experience in indication selection 
  • Prior experience on teams that have successfully advanced research to the clinic

Benefits

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• 401(k) retirement plans.
• Education and health/fitness incentive programs.
• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days. 
• Reading budget! We will buy you books.
• Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

About Us

Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won't drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off.

Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.

Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)

More info at jobs.generalproximity.bio