Scientist - Integrated Resources, Inc
Cambridge, MA 02141
About the Job
Job Title: Scientist
Job Location: Cambridge, MA
Job Duration: 12 Months
Pay Range: $ 55.00/hr on w2
Summary:
Client is seeking a highly motivated Scientist I or Scientist II to join the Non-Viral Gene Therapy (NVGT) Team. The successful candidate will have hands-on experience in antibody and protein engineering, with a focus on bioconjugation chemistry. The candidate will work closely with the LNP formulation team to achieve extrahepatic delivery of LNPs.
Responsibilities:
Requirements:
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Job Location: Cambridge, MA
Job Duration: 12 Months
Pay Range: $ 55.00/hr on w2
Summary:
Client is seeking a highly motivated Scientist I or Scientist II to join the Non-Viral Gene Therapy (NVGT) Team. The successful candidate will have hands-on experience in antibody and protein engineering, with a focus on bioconjugation chemistry. The candidate will work closely with the LNP formulation team to achieve extrahepatic delivery of LNPs.
Responsibilities:
- Execute protein conjugation reactions for both screening efforts and developability to enable nanoparticle targeting to specific cells and/or tissues.
- Perform downstream analytical assays such as SDS-PAGE, SEC-HPLC, RP-HPLC, BLI, DSF, CE-SDS and/or flow-cytometry.
- Perform incorporation of targeting antibody into LNPs and execute associated analytical assays, including DLS, zeta potential, nucleic acid content, endotoxin
- Design protein and antibody molecules at the primary sequence level
- Support management of CRO for molecule production
- Closely work with therapeutic area biologists and project teams to design functional experiments and interpret data
- Execute and carefully document experiments using electronic laboratory notebook system and clearly communicate results to team members.
- Plan, execute, and record experiments as guided in a time sensitive manner.
- Assume responsibility for critical reagent sourcing and maintain adequate supply and inventory.
- Author standard operating procedures, study plans and reports and present findings.
- Foster creativity, productivity, execution with a sense of urgency, scientific integrity and accountability. Maintains a collaborative culture.
Requirements:
- PhD in Chemistry, Biology, Biological Engineering, or a related field with a minimum of 1-3 years of relevant industry experience.
- Strong experience with protein and antibody engineering workflows, including primary sequence design, expression, purification, characterization
- Direct experience with site-specific bioconjugate chemistry
- Strong analytical biochemistry experience for protein and antibody engineering
- Proficient in performing structure-function analysis and bioinformatic analysis of antibodies, antigens, and other proteins
- Experience with automation and high throughput platform(s)
- Experience with BiProducter Interferometry or equivalent technique
- Preferred use of computational and AI/ML approaches for rational protein engineering, including AI 3D structure prediction, homology modeling, antibody/antigen docking, other relevant experience
- Preferred familiarity with formulation and analysis of lipid nanoparticles for research use
- Outstanding written and oral communication skills along with the ability to work collaboratively in a team setting.
- Demonstrated knowledge and skills in solving scientific problems, ability to troubleshoot, and willingness to learn.
- Demonstrated ability to independently design, execute, interpret, and present experimental results.
- Flexibility to adapt to rapidly changing priorities and deadlines in a dynamic, fast paced industry and work environment.
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Source : Integrated Resources, Inc