Scientist - Analytical Chemistry at SonoThera

Location: South San Francisco, CA

Status: Regular Full-Time

Reports To: Associate Director, Gene Therapy

About SonoThera:

SonoThera is a venture capital-backed early-stage biopharmaceutical company developing ultra-sound-guided non-viral targeted gene therapies to treat multiple diseases of high unmet need. The Gene Therapy group at SonoThera uses a collaborative, interdisciplinary, and forward-thinking approach to solving many of the current challenges facing genetic medicine discovery and drug development. SonoThera is headquartered in South San Francisco, CA.

Job Summary:

The Gene Therapy group at SonoThera is seeking to hire a Scientist to become an integral part of the gene therapy drug development effort. We seek candidates who think critically and have the desire and ability to learn new techniques. This position requires adaptability and an ability to perform at a high level in a fast-paced environment. The ideal candidate will leverage their mass spectrometry and chromatography expertise to develop assays in support of SonoThera’s gene therapy programs.  

Qualifications:

• Ph.D. with 2+ years or M.S. with 6+ years of industry experience in analytical chemistry, chemical biology, biochemistry or a related field. 

• Creativity and the ability to work within an interdisciplinary team to achieve technical and corporate milestones. 

• Ability to thrive in a fast-paced, start-up environment. 

• Strong verbal and written communication, critical thinking, and problem-solving skills. 

Technical Requirements and Skills:

• Extensive expertise in the development of analytical assays to support drug product characterization, including LC/UV, LC/MS, CE, and biochemical readouts. 

• Successful development of proteomic and metabolic assays is preferred. 

• Knowledge of purification with different chromatography methods including HPLC, IEX, and SEC for protein conjugations. 

• Previous experience using state-of-the-art LC-MS equipment for MRM/SRM and TOF analysis (Shimadzu, Agilent, Waters, ExionLC AE, Sciex). 

• Analyze proteomics data using proteomics analysis software (Skyline) and bioinformatics tools for protein and peptide quantification. 

• Working knowledge with recombinant protein downstream purification and characterization. 

• Research literature and external sources and identify new techniques and procedures. 

• Ideal candidate will have familiarity with ELNs (i.e. Benchling), Olink-based proteomics, MSD, Western blot, metabolomics and unbiased proteomics analysis. 

• Strong record-keeping and organizational skills. 

Compensation: The salary range for this temporary position is $125,000.00 to $150,000.00 USD annually. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.

At SonoThera, we'll give you the tools to feel healthy, happy and secure.

Equity and ownership in a fast-growing company.

Access to a 24-hour gym

Comprehensive medical, dental, and vision

Commuting stipend based on your geographical location

401(k) Match: SonoThera offers a dollar-for-dollar match

All full-time employees are eligible for our flexible time off policy

Equal Opportunity for Diversity & Inclusion

SonoThera provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.