We are seeking a Research Technician IV to join a dynamic and growing team at the Walter Reed Army Institute of Research (WRAIR) Wound Infection Department (WID). WID is tasked with delivering specific, effective countermeasures for infection of combat wounds pre-injury, at the point-of-injury, and post-injury. The Human Monoclonal Antibody Platform (HMAP) group focuses on in vitro and in vivo research of virulence factors associated with ESKAPEE pathogens and developing monoclonal antibodies against them.Responsibilities:
The candidate will perform a variety of laboratory procedures and be familiar with the field's concepts, practices and procedures including, but not limited to, microbiology, immunology and molecular biology. The candidate will work as part of a scientific team to understand and resolve complex biological questions while contributing to product development through the analysis and interpretation of data and presentation of findings at meetings. Under the guidance of the HMAP head, the candidate will actively pursue the scientific objectives of the Branch and contribute significantly to the execution of required studies.
Duties include, but not limited to:
- Serve as a technical expert in microbial pathogenesis, microbial genetics, genomics and related virulence factors in one or more of the ESKAPEE pathogens (Enterococcus species, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter cloacae, and Escherichia coli) (a minimum of five studies or as required)
- Perform research on monoclonal antibody development for microbial pathogens of military relevance and animal testing
- Develop and recommend research protocols and experimental techniques on monoclonal antibody development for submission and approval by the department chief (a minimum of five studies or as required) and report to the COR annually.
- Conduct research on projects associated with virulence factors and monoclonal antibody development for one or more of the ESKAPEE pathogens (Enterococcus species, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter cloacae, and Escherichia coli) (a minimum of five studies or as required).
- Plan, coordinate and perform microbiological studies on virulence factors and monoclonal antibody development, to include animal modeling, under biosafety level two (a minimum of five studies or as required).
- Express and purify recombinant proteins for antibody production, deliver antibodies, crystallize antigen: antibody complexes and mass spectrometry of all products.
- Keep accurate and complete records of research done in accordance with applicable standards.
- Submit reports and data summaries as requested and prepare research results for presentation and publication in the scientific literature.
- Provide all job-related progress reports/technical reports as requested.
- Maintain laboratory operation to include insuring stocks of laboratory supplies and reagents, ordering supplies and preparing supply requests for approval, annual inventory of micro-organisms, annually updating of technical research support area SOPs, maintaining a supply of clean glassware, properly disposing of hazardous biological and chemical waste, preparing reagents, and maintaining an inventory of laboratory chemicals, orderliness and cleanliness.
- Maintain a safe workplace ensuring that he/she is aware of and observes appropriate safety and occupational health rules and regulations.
- Comply with occupational health and safety standards and complete all required safety, biosafety and security training classes as established by WRAIR as minimal standard in the Joint Safety Manual.
- Obtain required occupational physical examinations, annual serologic tests and any required security clearance to conduct work in department laboratories.
- Performs light duties and other related duties as required and assigned.
- Night and weekend hours may be required
- Must be a US Citizen
- B.S. or M.S. in appropriate discipline (e.g., microbiology, immunology, molecular biology and biochemistry).
- Experience with small animal models required.
- Experience with antibody development is required.
- Proficiency in basic laboratory techniques and mathematics skills required.
- Must have ability to perform work at a high level of accuracy and maintain detailed records of research.
- Strong computer skills and experience with relevant software including MS Office and GraphPad Prism.
Odyssey Systems Consulting Group, is an innovative small business committed to providing world-class technical, management, and training support services to government and public sector clients. We focus on people, processes, and performance to deliver superior results. Since our inception in 1997, our commitment to mission success and customer satisfaction has been recognized with exponential growth and exceptional past performance ratings. We accept challenging assignments and drive projects from the planning stages, through implementation, and into operations and support.
Please note: Final compensation for this position will be determined by various factors such as the Federal Government contract labor categories and contract wage rates, relevant work experience, specific skills and competencies, geographic location, education, and certifications.
Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities