Research Scientist - Lab Core Manager-(3283569) - Partners Healthcare System

About Us:

As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community by leading innovation across our system. Founded by Brigham and Women’s Hospital and Massachusetts General Hospital, Mass General Brigham supports a complete continuum of care including community and specialty hospitals, a managed care organization, a physician network, community health centers, home care and other health-related entities. Several of our hospitals are teaching affiliates of Harvard Medical School, and our system is a national leader in biomedical research.

We’re focused on a people-first culture for our system’s patients and our professional family. That’s why we provide our employees with more ways to achieve their potential. Mass General Brigham is committed to aligning our employees’ personal aspirations with projects that match their capabilities and creating a culture that empowers our managers to become trusted mentors. We support each member of our team to own their personal development—and we recognize success at every step.

Our employees use the Mass General Brigham values to govern decisions, actions and behaviors. These values guide how we get our work done: Patients, Affordability, Accountability & Service Commitment, Decisiveness, Innovation & Thoughtful Risk; and how we treat each other: Diversity & Inclusion, Integrity & Respect, Learning, Continuous Improvement & Personal Growth, Teamwork & Collaboration.

GENERAL SUMMARY / OVERVIEW:

The Gene and Cell Therapy Institute (GCTI) is a newly created system-wide Institute under Mass General Brigham. The Institute will foster a world-class gene and cell therapy program that will leverage ongoing, groundbreaking scientific research efforts across the MGB system.

The mission of GCTI is to bring together the community of MGB investigators which can utilize gene and cell therapy platforms to achieve their scientific and clinical goals and improve the health of patients. The Institute will differentiate itself by harnessing the exceptional strengths of clinician scientists, the large and unique patient population, and major discoveries throughout the hospital system to propel MGB as the leader in Gene & Cell therapies.

The Abudayyeh-Gootenberg Gene Editing lab at the Mass General Brigham Gene and Cell Therapy Institute is seeking a highly organized and dynamic individual to serve as a manager and principal scientist for a new Gene Editing and Perturbation (GEP) core housed at the GCTI. This unique role provides an opportunity to be a part of a team contributing to the forefront of technology development in gene therapy, cell therapy, and aging research and supporting the entire MGB ecosystem’s research and development in the gene editing and genomic perturbation space.

This position is designed for a motivated and skilled individual who will be instrumental in managing the GEP’s operations. The GEP is a new model, established by the GCTI, to assist researchers both across MGB and external groups with performing gene editing experiments and pooled genetic screens. Successful candidates will play a pivotal role in establishing the core, hiring additional members to assist with core activities, setting up initial services, and working with potential investigators in the MGB ecosystem. Additionally, there is the opportunity to engage in cutting-edge research and collaborations, including but not limited to publishing results, assisting with pre-clinical asset development, and eventually in scale up of reagents for clinical trials.

We are looking for someone who thrives in a fast-paced, innovative environment and is passionate about supporting science that makes a difference. The ideal candidate will be highly organized, possess exceptional planning skills, and demonstrate a strong curiosity about the work. Furthermore, existing experience with genome editing, CRISPR, lentiviral preparation, and pooled screening is strongly preferred.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

Core Management

· Oversee daily operations of the GEP core, ensuring efficient workflow and compliance with safety regulations.

· Establish systems and infrastructure for accepting orders and billing customers.

· Ensure proper and timely production of requested samples.

· Setting up initial lab services and activities.

· Assist clients with critical know-how for designing and debugging experiments.

· Recruiting additional core staff as needed.

Scientific Support

· Purify lentiviral libraries for pooled genetic screening.

· Transduce cell lines with libraries.

· Harvest DNA and analyze NGS results of pooled screens.

· Perform cell sorting as needed to read out screens.

· Handle primary cell lines for genome editing experiments.

· Design and test guide RNAs for CRISPR technologies, including nucleases, CRISPRi, base editing, and prime editing.

· Delivery genome editing reagents to cell lines and primary cells using diverse delivery technologies, including DNA lipofection, mRNA delivery, viral transduction, and electroporation.

· PhD in n a relevant scientific discipline.

· Experience with genome editing and CRISPR technologies.

· Experience with genome-wide screening.

· Prior experience in lab management and leadership is helpful.

· Strong organizational skills and the ability to multitask effectively.

· Excellent communication skills, both written and verbal.

· Proficiency in office and lab software, including Microsoft Office Suite and laboratory information management systems (LIMS).

· Knowledge of laboratory safety and compliance regulations.

· Demonstrated ability to work independently as well as part of a team.

SKILLS/ ABILITIES/ COMPETENCIES:

· High degree of computer literacy

· Sound analytical and organizational skills.

· Requires good oral and written communication skills.

· Must be able to logically and effectively structure tasks and set priorities.

· Ability to identify problems in the lab and trouble-shoot solutions.

· Independent drive and motivation

Mass General Brigham is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.