Research Scientist II, Downstream - Novartis
San Diego, CA
About the Job
Position is on-site in San Diego, CA
#LI-Onsite
About the role:
The Biologics Research Center (BRC) Cell & Gene Therapy unit at Novartis Biomedical Research in San Diego, California is seeking a motivated Research Scientist II to contribute in early-stage recombinant adeno-associated virus (AAV) gene therapy portfolio. BRC is an innovative hub focuses on building new modalities that tackle complex biology and enable the creation of advanced biotherapeutics, siRNAs and cell & gene therapies to improve patients’ lives. In collaboration within BRC and with Disease Areas, the Cell & Gene Therapy unit brings viral engineering in AAV gene therapy to create transformative medicine.
The prospective Research Scientist will support early-stage AAV gene therapy pipeline portfolio focusing on downstream manufacture developability of novel AAV capsids, executing early-stage downstream method exploration and building improved process technologies for AAV manufacture.
Your Key Responsibilities:
Your responsibilities include, but are not limited to:
• Perform different scales of purification process including depth filtration, ultracentrifugation, AKTA column chromatography, and TFF unit operations for manufacturing of AVV gene therapy vectors across multiple early-stage programs and disease areas to ensure on time delivery.
• Execute experiments to drive innovative technology and platform evaluation for next generation capsids.
• Perform experiment-related activities including buffer preparation, equipment maintenance, sample labelling and analytical sample submissions.
• Work collaboratively with upstream process development and analytical development teams.
• Engage collaboratively in operational and scientific discussion within internal team
• Assist knowledge transfer and work collaboratively with Technical Research & Development team to advance pipeline programs into clinical phases.
• Prepare protocols, reports, and provide high quality data and electronic notebook documentation.
• Other related duties as assigned.
This position will be located at the San Diego, CA site and will not have the ability to be located remotely.
#LI-Onsite
About the role:
The Biologics Research Center (BRC) Cell & Gene Therapy unit at Novartis Biomedical Research in San Diego, California is seeking a motivated Research Scientist II to contribute in early-stage recombinant adeno-associated virus (AAV) gene therapy portfolio. BRC is an innovative hub focuses on building new modalities that tackle complex biology and enable the creation of advanced biotherapeutics, siRNAs and cell & gene therapies to improve patients’ lives. In collaboration within BRC and with Disease Areas, the Cell & Gene Therapy unit brings viral engineering in AAV gene therapy to create transformative medicine.
The prospective Research Scientist will support early-stage AAV gene therapy pipeline portfolio focusing on downstream manufacture developability of novel AAV capsids, executing early-stage downstream method exploration and building improved process technologies for AAV manufacture.
Your Key Responsibilities:
Your responsibilities include, but are not limited to:
• Perform different scales of purification process including depth filtration, ultracentrifugation, AKTA column chromatography, and TFF unit operations for manufacturing of AVV gene therapy vectors across multiple early-stage programs and disease areas to ensure on time delivery.
• Execute experiments to drive innovative technology and platform evaluation for next generation capsids.
• Perform experiment-related activities including buffer preparation, equipment maintenance, sample labelling and analytical sample submissions.
• Work collaboratively with upstream process development and analytical development teams.
• Engage collaboratively in operational and scientific discussion within internal team
• Assist knowledge transfer and work collaboratively with Technical Research & Development team to advance pipeline programs into clinical phases.
• Prepare protocols, reports, and provide high quality data and electronic notebook documentation.
• Other related duties as assigned.
This position will be located at the San Diego, CA site and will not have the ability to be located remotely.
Source : Novartis