Research Associate/Sr. Research Associate, Molecular Biology - Cabaletta Bio Inc.

Philadelphia, PA

Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on developing and launching targeted, potentially curative, cellular therapies for patients with autoimmune diseases. The CABA™ platform includes two strategies to treat and potentially cure many of the most common and challenging autoimmune diseases. The CARTA strategy, or Chimeric Antigen Receptor T cells for Autoimmunity, is designed to potentially reset the immune system by causing transient B cell depletion with early academic clinical data suggesting the potential of this strategy to transform treatment in patients with SLE and the possibility of cures in rheumatoid arthritis, myositis, and systemic sclerosis, among others. Our lead product candidate using the CARTA strategy is CABA-201, 4-1BB-containing CD19-CAR T designed specifically to treat patients with autoimmune diseases with high unmet need, including systemic lupus erythematosus (SLE), myositis, systemic sclerosis, and generalized myasthenia gravis, and which uses a CD-19 binder that has an encouraging clinical tolerability profile. In addition to our CARTA candidate, CABA-201, we have a clinical-stage pipeline of Chimeric AutoAntibody Receptor T (CAART) cells targeted to the cells responsible for autoantibody-mediated autoimmune diseases.  Cabaletta Bio’s headquarters are located in Philadelphia, PA. For more information, visit www.cabalettabio.com and follow us on LinkedIn and X (Twitter). 

Uniquely Differentiated. Rapid. Elegant. 

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew.  

We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great:  Working at Cabaletta Bio Inc | Great Place to Work® 

About the Position

Reporting to the Associate Scientist, Molecular Biology group, we are seeking an experienced and motivated Research Associate or Senior Research Associate. Under scientific and technical supervision, the candidate will design and execute cell-based assay advancing multiple discovery programs. The position offers growth into additional areas such as cell biology and molecular biology, immunology, and cell therapy. The position involves both technical and operational responsibilities.

Responsibilities:

• Conducting routine cell culturing and cell-based assay development.
• Maintaining, expanding, banking, and managing various cell lines, including CAR-T cells.
• Performing cytotoxicity and flow cytometry assays as needed.
• Molecular Cloning - Experience with restriction digest and TA TOPO based cloning, DNA gel electrophoresis, and bacterial transformation
• Supporting new preclinical discovery projects by working closely with scientists in the lab to execute key experiments.
• Providing cross-functional exposure and contributing to projects spanning various departments.
• Actively contributing to process improvements and the implementation of new technologies.
• Performing lab associated tasks in accordance with cGLP and Cabaletta Bio lab safety policies.
• Maintaining accurate and well-organized records and electronic laboratory notebook.

Preferred Qualifications

• B.S degree in Life Sciences or closely related discipline with 0-2 years of prior experience.
• Prior experience with cell culture and cell-based assay development and T-cell biology.
• General lab skills, including sterile techniques and human tissue handling.
• Experience with flow cytometry is advantageous.
• Must be highly organized and able to work independently.
• Must be able to clearly communicate in writing, must have a desire to be part of a growing organization that uses cutting-edge science.
• A high level of flexibility to support various other activities and the ability to learn new techniques outside of existing field of expertise. 
• Strong team orientation and passion for continuous self-development.
• Experience in industry or in a startup industrial setting is preferred.

Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression. 

For more information, please visit  https://www.cabalettabio.com/join-our-crew 

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.  

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. 

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation. 

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.