Senior Research Associate I, In Vitro Pharmacology - Keros Therapeutics
Lexington, MA
About the Job
Keros Therapeutics is a public, clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of novel treatments for patients suffering from hematological and musculoskeletal disorders with high unmet medical need. We are a leader in understanding the role of the transforming growth factor-beta, or TGF-ß, family of proteins, which are master regulators of red blood cell and platelet production as well as of the growth, repair and maintenance of muscle and bone. We have leveraged this understanding and developed a discovery approach to generate large and small molecules to address diseases of these tissues. Targeting TGF-ß signaling pathways has been clinically proven to elicit robust changes in blood cells, muscle, and bone, which we believe provides a precedent and strong rationale for our strategy.
We are seeking a highly motivated Biology/Biochemistry Sr. RA to join our In Vitro Pharmacology team. You will be able to work alongside our team to design and execute in vitro experiments that support preclinical drug discovery, including disease modeling and proof of mechanism validation to characterize our platform candidates. The ideal candidate is a skilled lab-based in vitro biologist driven to contribute to a rigorous scientific environment and a consummate team player. This is a great opportunity to become an integral member of a diverse drug discovery team with ample prospects to progress their career development in drug discovery.
Responsibilities:
- Execute a wide array of experiments in cellular and molecular biology.
- Perform cell culture routinely; establish and characterize innovative cell lines for disease modeling and pharmacology studies.
- Develop protocols for diverse assays, meticulously documenting and sharing research findings with colleagues.
- Actively contribute to the design and troubleshooting of experimental studies, nurturing collaboration with biology teams and cross-functional project groups.
- Provide essential support for the daily operations of biology labs.
- Proactively review the literature to bring in the newest scientific findings, ideas, methods, and technologies for discovery research
- Maintain accurate and detailed laboratory records.
- Collaborate with team members on multiple research projects.
Qualifications:
- M.S. or B.S. in cell biology or related disciplines.
- A minimum of 2-5 years of hands-on experience in cellular and molecular biology techniques, including but not limited to flow cytometry, RT-qPCR, western blotting, siRNA/shRNA silencing, CRISPR/CAS9 knockout, plasmid construction and preparation, lentiviral/retroviral transduction, and ELISA-based assays.
- Proficiency in cell culture techniques, including both immortalized cell lines and primary cells.
- Previous exposure to organoids or multicellular culture models is highly regarded.
- Experience in Flow Cytometry is advantageous.
- Excellent written and verbal communication skills, as well as strong organizational and problem-solving abilities.
- Enthusiasm for scientific research and a desire to learn and contribute.
Our Diversity, Equity & Inclusion Mission Statement: Keros is an inclusive company. We believe that diversity drives innovation. We continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our employees. As such, Keros takes a holistic approach in mentoring, coaching, and developing all of our Keros team members.
Keros Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.