Principal Scientist I- (Protein Science) - ModeX Therapeutics Inc .

This is an exciting time to join our cutting-edge organization! ModeX Therapeutics, an OPKO Health company, is developing the next generation of multi-specific antibodies as novel therapies for cancer and infectious diseases, as well as nanoparticle technologies for the development of next generation vaccines. Join our team of groundbreaking scientists today and change the world tomorrow.​​​​​​​

ModeX Therapeutics, an OPKO Health Company, is seeking a highly skilled and motivated molecular biologist and biochemist to join our Protein Science team. The individual will be part of an established multidisciplinary team to design, produce and characterize novel therapeutic antibodies.  This is an exciting opportunity to be part of a cross-functional team and contribute to the development of cutting-edge biotherapeutics in a fast-paced, rapidly growing biotech company with a bold vision.

Company

ModeX is a clinical-stage biopharmaceutical company developing next-generation antibodies and vaccines for cancer and infectious disease.  ModeX's modular antibody platforms unite the power of multiple biologic components in a single molecule to design multispecific antibodies with great versatility and potency to fight complex disease. Our pipeline includes candidates against both solid and liquid tumors as well as several of the world’s most pressing viral threats. Our founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients.

Major responsibilities

• Effectively collaborate with colleagues with diverse scientific background and contribute to our interdisciplinary biologics research teams to drive the design and production of innovative therapeutic molecules, and the optimization of their biochemical/ biophysical properties.
• Serve as the SME of key platforms including molecular biology, mammalian expression and protein purification, supervise junior scientists and lead the protein production team to carry out high-throughput molecular cloning, protein expression and purification tasks.
• Independently perform routine biochemical/biophysical QC and functional characterization of tool and therapeutic molecules.
• Be responsible for experimental planning, execution, data analysis/interpretation, and communication with cross-functional teams for successful completion of projects.
• Stay scientifically current and contribute to the implementation of innovative technology and instrumentation to improve current workflow for multispecific antibody engineering, production and screening.
• Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks.

Qualifications

• PhD in molecular biology, biochemistry, structure biology or other life science disciplines with 12+ years of relevant experience.
• Skilled in common molecular biology techniques such as Gibson assembly and Golden Gate cloning, mammalian cell culture and recombinant protein expression using both transient and stable expression platforms.
• Proficient with various protein purification techniques including affinity, IEX and SEC chromatography and AKTA purification platform.
• Familiar with protein characterization and analytics technologies including BLI/SPR, ELISA, FACS, and HPLC/UPLC.
• Knowledge in antibody structure and function, and experience in antibody drug discovery and multispecific antibody development are preferred.
• Working proficiency in structural analysis tools such as Pymol, BioLuminate, or MOE.
• Experience in protein crystallography or cryoEM is desired.
• Track record of scientific accomplishments as evidenced by a strong publication record and a drive for self-development with a focus on scientific know-how.
• Excellent written and oral communication, organization, and data analysis skills. Outstanding troubleshooting and problem-solving skills.
• Highly adaptable to a fast-paced work environment and capable of working both independently and collaboratively within project teams.

ModeX Therapeutics is an Equal Opportunity Employer