Principal Research Scientist I Chemistry - AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. 

AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013, following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise and capabilities of a long-established pharmaceutical leader, to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie employs approximately 50,000 people worldwide and markets medicines in more than 170 countries.

AbbVie is seeking a Principal Research Scientist I to conduct process research and development of small molecules from pre-clinical through early clinical phases.

Key Responsibilities:

• We seek a highly motivated scientist, with a proven track record of accomplishment in the biopharmaceutical industry, to work in a cross-functional team environment. The qualified candidate will deliver results in a team-oriented setting.
• The successful candidate will be responsible for setting project strategies, defining project responsibilities and timelines, providing leadership in a matrixed team setting and developing robust processes for cGMP manufacturing of AbbVie’s small molecule and/or antibody-drug conjugate candidates.
• The successful candidate will conceive of and develop synthetic routes for preclinical (GLP tox) and first in human (FIH) clinical deliveries, develop manufacturing processes, demonstrate processes in the API Pilot Plant, and establish appropriate control strategies.
• The position involves multi-disciplinary interactions with organic chemists, analytical chemists, engineers, solid state scientists, drug product development, program management, external partners, etc.  The selected candidate will collaborate with Discovery Teams, Development Sciences Core Teams, and Asset Strategy Teams to advance preclinical and clinical candidates. It is expected that the candidate will utilize their expertise across CMC disciplines to generate collaborations with drug product development and regulatory affairs to further program goals.
• The ideal candidate will have strong verbal and written communication skills, and will serve as the lead author on development reports and as a key contributor to regulatory filings.

• PhD in Chemistry with 6+ years of relevant experience or MS in Chemistry with 12+ years of relevant experience or BS in chemistry with 14+ years of relevant experience.  Candidates with less experience may be considered for other opportunities.
• Proven scientific leadership; strong interpersonal and communication skills for facilitating collaborations and a demonstrated ability to lead cross-functional process development teams.
• The successful candidate will have a strong understanding of modern organic chemistry and mechanistic theory, control strategy development and regulatory starting material strategies.  
• An understanding of global regulatory expectations and experience with authoring development reports and regulatory filings is highly desirable.
• Demonstrates creative 'out of the box' thinking to solve difficult technical problems and champion new strategies/technologies to achieve project goals.

Key Leadership Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
• Learns fast, grasps the "essence", and can change course quickly where indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation, and manages innovation to reality.

Level and compensation will be commensurate with experience.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.