Lab Associate Director at Jobot
Cambridge, MA 02142
About the Job
Competitive Pay! Full Benefits! Bonuses + More!
This Jobot Job is hosted by: Juan Correa
Are you a fit? Easy Apply now by clicking the "Quick Apply" button
and sending us your resume.
Salary: $120,000 - $160,000 per year
A bit about us:
We are developing cures for other genetic epilepsies and CNS indications. Beyond CNS we are also pursuing non-CNS indications caused by haploinsufficiency and/or nonsense mutations.
Why join us?
Job Details
As an expert scientist in RNA biology, you will be responsible for establishing cellular assays to demonstrate in vitro proof of concept for our tRNA therapeutic leads and characterize the cellular activity and downstream disease-relevant biology to help prioritize candidates for in
vivo studies.
Key Responsibilities
Minimum Qualifications
Interested in hearing more? Easy Apply now by clicking the "Quick Apply" button.
This Jobot Job is hosted by: Juan Correa
Are you a fit? Easy Apply now by clicking the "Quick Apply" button
and sending us your resume.
Salary: $120,000 - $160,000 per year
A bit about us:
We are developing cures for other genetic epilepsies and CNS indications. Beyond CNS we are also pursuing non-CNS indications caused by haploinsufficiency and/or nonsense mutations.
Why join us?
- Great Competitive Base Salary!
- Yearly Bonuses! Stock Options!
- Competitive PTO!
- 401K Match!
- Full Benefits!
Job Details
As an expert scientist in RNA biology, you will be responsible for establishing cellular assays to demonstrate in vitro proof of concept for our tRNA therapeutic leads and characterize the cellular activity and downstream disease-relevant biology to help prioritize candidates for in
vivo studies.
Key Responsibilities
- Design, troubleshoot, and execute RNA assays in both primary cells and cell lines to characterize the efficacy and safety of our novel tRNA therapeutic leads.
- Oversee all aspects of library production and data analysis for RNA-sequencing experiments.
- Work with in vivo team members to translate in vitro findings into relevant animal models.
- Characterize mechanisms linking mRNA stability, translation efficiency, and codon optimality.
- Demonstrate a mastery of relevant scientific literature and advances in the areas of tRNA and post-transcriptional mRNA regulation
Minimum Qualifications
- A Ph.D. in Molecular/Cellular Biology, Biochemistry, or a related discipline with a track record of relevant scientific publications in peer-reviewed journals.
- Applicants must possess a strong background in RNA-based therapies, mRNA translation & stability, ribosomal function, post-transcriptional regulation of gene expression, codon optimality, and/or tRNA biology.
- Expertise in the analysis of RNA-sequencing data is required. Prior experience with tRNA-seq, single-cell sequencing, and/or ribosome profiling/ribo-seq is highly desirable.
- Extensive hands-on experience with a variety of molecular, cellular and biochemical approaches, with an emphasis on RNA-based techniques: e.g., Northern analysis, metabolic labeling to quantify mRNA stability, in situ hybridization, etc. Familiarity with cell or primary neuronal culture, droplet digital PCR (ddPCR) & qPCR platforms, and viral delivery protocols is preferred.
- Ability to work independently as well as collaborate with colleagues and effectively prioritize and manage multiple tasks in a fluid, fast-paced work environment.
- Ability to master new concepts and technologies quickly and run experiments independently.
- Scientifically rigorous, highly organized, with excellent oral and written communication skills.
Interested in hearing more? Easy Apply now by clicking the "Quick Apply" button.
Salary
120,000 - 160,000 /year