Head / VP of Biology (Discovery, Small Molecule, Oncology) San Diego Hybrid - Z-Alpha Therapeutics

Based in San Diego, Z-Alpha Therapeutics is a pharmaceutical company dedicated to the discovery and development of radiotherapeutics targeting key biological pathways for solid tumors. The company has a revolutionary technology platform in the next generation of alpha particle therapy with potential to be a more targeted therapy, increasing efficacy and limiting toxicity compared to competitors in the radiotherapeutics space. The company has a world-class team of scientists with decades of experience and foundational intellectual property that enables the potential to bring multiple drug candidates into the clinic.

JOB SUMMARY:

The Head of Biology will lead the discovery and validation of novel therapeutic targets in oncology, overseeing drug discovery activities from early-stage research to preclinical development. The position also includes mentoring project leaders, managing teams, and fostering cross-functional collaborations to accelerate oncology treatments toward clinical application.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Spearhead the discovery of new, high-value therapeutic targets for the oncology pipeline.
• Develop and implement strategies for identifying novel targets within specific patient populations.
• Oversee biology efforts for innovative oncology therapeutic programs, ensuring timely and strategic delivery of actionable data.
• Prioritize projects and manage resources to support organizational goals.
• Foster strong cross-functional collaboration within the discovery organization.
• Effectively communicate scientific progress and strategy internally and externally.
• Stay informed on competitive intelligence and advancements in oncology by interacting with experts, attending scientific meetings, and reviewing literature.
• Promote a culture of scientific excellence and support career growth for a team of cancer biologists.
• Support business development strategies and needs
• Perform additional duties as assigned.

EDUCATION/KNOWLEDGE/SKILLS/ABILITIES REQUIRED:

• Ph.D. in Biology-related field, with 12+ years of progressive biotech/pharma experience.
• Deep understanding of oncology and the current therapeutic landscape.
• Proven success in moving projects from target discovery to early development, including lead identification and optimization.
• Strong interpersonal skills, capable of influencing key scientific decisions and collaborating with stakeholders. A strategic thinker able to balance the big picture with detailed program execution.
• Strong leader who can develop and lead teams to a high level of performance, within an evolving and fast-paced environment.
• Exceptional communication and presentation skills. Creative thinker who is innovative and open to new ideas and ways of working
• Experience managing external research collaborations with contract research organizations and academic partners. Experience with regulatory filings (IND, IB, NDA) is preferred. Experience in radiopharmaceuticals is preferred, but not required.