Computational Biologist (Principal Scientist) at Amgen

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Lets do this. Lets change the world. The Computational Biology group in the Center for Technology and Innovation (CfTI) within the Precision Medicine organization at Amgen is seeking a highly motivated Computational Biologist with expertise in analyzing clinical biomarker data, including but not limited to genomics, transcriptomics, proteomics, spatial-omics, flow cytometry, immunoassays, and other biomarker assays. In this vital role you will contribute to advancing Amgens clinical programs and studies by integrating computational biology and bioinformatics techniques with biological and clinical data. The ideal candidate will have experience in matrixed environments, supporting therapeutic development by providing insights derived from clinical biomarker data. A background in inflammation and immunology, rare diseases, or cardiometabolic disease is preferred to support key areas of Amgen's therapeutic focus.

• Support Amgen program/portfolio teams as a biomarker analysis lead.

• Development of biomarker analysis plans to support precision medicine, evidence generation and reverse translation during clinical development of therapeutic molecules.

• Design and execute workflows for biomarker data analysis, integrating genomics, transcriptomics, proteomics, imaging and biomarker measure using other assays/platforms to support Amgen's early and late clinical development programs.

• Lead the analysis and interpretation of clinical biomarker data from various assay platforms, including imaging, flow cytometry, immunoassays, transcriptomics, proteomics, and spatial-omics, etc.

• Design and implement computational algorithms to analyze multi-omics, multi-modal, and high-content data, with applications in target engagement evaluation, patient stratification, response prediction, indication selection, assay development, and diagnostic development.

• Work closely with clinical scientists and biomarker leads, to extract biological insights from high-dimensional datasets and integrate them into reverse translational research and clinical development plans.

• Collaborate cross-functionally with early development teams, biostatistics, clinical pharmacology, clinical biomarker leads, and research teams to manage data integration, analysis, and presentation.

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications:

• Doctorate degree and 2 years of scientific experience

Or

• Masters degree and 5 years of scientific experience

Or

• Bachelors degree and 7 years of scientific experience

Preferred Qualifications:

• PhD in Bioinformatics, Mathematics, Computer Science, Computational Biology or Data Science, with a minor or robust background in Biology

• Hands-on experience in statistical modeling, machine learning, and AI applied to clinical biomarker and clinical efficacy data.

• A strong understanding and practical skills in statistics and their use in data analysis for clinical settings

• Proven expertise in analyzing multi-modal, multi-dimensional, and large-scale biological data.

• Prior experience working in a matrixed biotechnology or pharmaceutical setting.

• Proficiency in R and Python programming, with familiarity in various principles for data manipulation and visualization.

• Strong understanding of platforms used in clinical biomarker research, including flow cytometry, immunoassays, next-generation sequencing (NGS), and proteomics.

• Knowledge of immunology, autoimmune diseases, cardiometabolic disease or oncology, and how computational biology can drive drug discovery and development in these areas.

• Ability to translate biological and medical questions into analytical models providing actionable results

• Excellent written and oral communication skills with the ability to present complex data analyses in diverse settings, including cross-functional team meetings, external collaborations, and scientific publications.

• Strong project management skills and organizational awareness, self-motivation, independence, and leadership

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans

• Flexible work models, including remote and hybrid work arrangements, where possible

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.