Bioprocess Engineer/Senior Bioprocess Engineer - Cell Production & Process Development - United Therapeutics
Manchester, NH
About the Job
California, US residents click here (https://www.unither.com/docs/UNITHER%20Applicant%20Notice%20-%20%2812-22-23%29%20Final%202.15.24%20Combined%20EN%20and%20French.pdf#page=9) .
The job details are as follows:
Flexibility for weekend work required as needed
What We Do
We build on the strength of our research and development expertise and a distinctive, entrepreneurial culture that encourages diversity, innovation, creativity, sustainability, and, simply, fun. Since inception, our mission has been to find a cure for pulmonary arterial hypertension and other life-threatening diseases. Toward this goal we have successfully gained FDA approval for five medicines, we are always conducting new clinical trials, and we are working to create an unlimited supply of manufactured organs for transplantation.
We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation (PBC). Our public benefit purpose is to provide a brighter future for patients through (a) the development of novel pharmaceutical therapies; and (b) technologies that expand the availability of transplantable organs. At the same time, we seek to provide our shareholders with superior financial performance and our communities with earth-sensitive energy utilization.
Our company was founded by an entrepreneur whose daughter was diagnosed with a life-threatening condition. She sought to find treatment options and a cure for her daughter and patients like her. We are founder-led, and relentless in our pursuit of “medicines for life”. We continue to research and develop treatments for cardiovascular and pulmonary diseases, and other orphan diseases.
How you’ll contribute
The Bioprocess Engineer, Cell Production and Process Development (OMG) will contribute to efforts related to the scale up and process development of robust methods to produce iPS-derived autologous cells for 3D printed organs in a GMP setting. Additionally, this role will contribute to supplying primary and iPSC-derived cells for R&D tissue engineering efforts.
+ Contribute to the design and execution of process development studies to scale-up iPSC differentiation processes to multiple cell types and develop robust, cGMP manufacturing processes
+ Contribute to the production effort to provide sufficient cells for R&D cellularization and tissue engineering efforts of 3D printed scaffolds
+ Assist in developing, writing, and reviewing laboratory methods and protocols
+ Assist in evaluating new technologies for future process development
+ Interact with manufacturing and quality teams to ensure process and methods for production of iPS-derived cells are cGMP ready
+ Contribute to tech transfer activities from outside collaborators to internal laboratory and from internal PD efforts to cGMP manufacturing sites
+ Participate in selection, purchase, and implementation of laboratory equipment
+ Foster and leverage synergistic interactions with other sub-groups in Organ Manufacturing (e.g., Bioink, Scaffold Production, Cellularization), as needed
+ Author and contribute to scientific publications and present data at scientific conferences
+ Perform other duties as assigned
For this role you will need
Minimum Requirements
+ BIOPROCESS ENGINEER: 3+ years of relevant industry experience with prior experience in stem cell therapy, bioreactor cell production scale up, regenerative medicine, tissue engineering with a BA/BS Degree in biomedical science, cell biology or related field OR 1+ years of relevant industry experience in stem cell biology, bioreactor cell production scale up, regenerative medicine, tissue engineering with a Master's Degree in biomedical science, cell biology or related field
+ SR LEVEL: 5+ years of relevant industry experience with prior experience in stem cell therapy, bioreactor cell production scale up, regenerative medicine, tissue engineering with a BA/BS Degree in biomedical science, cell biology or related field OR 3+ years of relevant industry experience in stem cell biology, bioreactor cell production scale up, regenerative medicine, tissue engineering with a Master's Degree in biomedical science, cell biology or related field
+ Strong working knowledge of cellular process development
+ Experience with cell bioreactor culture.
+ Experience with automated cell processing equipment such CliniMACS Plus, LOVO, Cue, Sepax, Sefia, Rotea or others
+ Knowledge in transfer of R&D cell expansion methods to GMP
+ Facility with appropriate word processing, spreadsheet, presentation and related standard software; Experience with laboratory instrumentation and data software
+ Excellent written and oral communication skills
+ Strong organizational skills and attention to detail
+ Must be able to accommodate a non-traditional work schedule (e.g. Sun-Thu, Tue-Sat)
Preferred Qualifications
+ Master’s Degree in biomedical science, cell biology or related field
+ Sartorius Ambr/B-DCU systems and/or vertical wheel bioreactors with scales up to 10L+ preferred.
At United Therapeutics, you’ll realize quickly that it is not an ordinary place to work! When you join our company, you will learn, grow, contribute, have fun, and be challenged... all while making a difference in the lives of our patients.
_While United Therapeutics does not require vaccination for Covid-19 at this time, we strongly encourage all employees and visitors to remain up to date on vaccinations and boosters to protect one another from illness. Employees working in customer-facing roles must adhere and comply with customers’ credentialing guidelines, which may require vaccination against Covid -19, the influenza virus, and other illnesses that could be harmful to healthcare staff and patients._
United Therapeutics Corporation is an Equal Opportunity/Affirmative Action Employer - EOE Minorities / Females / Protected Veterans / Individuals with Disabilities
_We strive to be an organization that engages the minds, hearts, and most spirited efforts of each of our employees. Our sense of purpose transforms what we do from work into mission, occupation into vocation and achievement into success._
_We challenge our employees with innovative and revolutionary projects, offer an environment which fosters high-level job performance and provide a highly competitive total rewards package. This is what makes United Therapeutics a stimulating place to work._
The job details are as follows:
Flexibility for weekend work required as needed
What We Do
We build on the strength of our research and development expertise and a distinctive, entrepreneurial culture that encourages diversity, innovation, creativity, sustainability, and, simply, fun. Since inception, our mission has been to find a cure for pulmonary arterial hypertension and other life-threatening diseases. Toward this goal we have successfully gained FDA approval for five medicines, we are always conducting new clinical trials, and we are working to create an unlimited supply of manufactured organs for transplantation.
We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation (PBC). Our public benefit purpose is to provide a brighter future for patients through (a) the development of novel pharmaceutical therapies; and (b) technologies that expand the availability of transplantable organs. At the same time, we seek to provide our shareholders with superior financial performance and our communities with earth-sensitive energy utilization.
Our company was founded by an entrepreneur whose daughter was diagnosed with a life-threatening condition. She sought to find treatment options and a cure for her daughter and patients like her. We are founder-led, and relentless in our pursuit of “medicines for life”. We continue to research and develop treatments for cardiovascular and pulmonary diseases, and other orphan diseases.
How you’ll contribute
The Bioprocess Engineer, Cell Production and Process Development (OMG) will contribute to efforts related to the scale up and process development of robust methods to produce iPS-derived autologous cells for 3D printed organs in a GMP setting. Additionally, this role will contribute to supplying primary and iPSC-derived cells for R&D tissue engineering efforts.
+ Contribute to the design and execution of process development studies to scale-up iPSC differentiation processes to multiple cell types and develop robust, cGMP manufacturing processes
+ Contribute to the production effort to provide sufficient cells for R&D cellularization and tissue engineering efforts of 3D printed scaffolds
+ Assist in developing, writing, and reviewing laboratory methods and protocols
+ Assist in evaluating new technologies for future process development
+ Interact with manufacturing and quality teams to ensure process and methods for production of iPS-derived cells are cGMP ready
+ Contribute to tech transfer activities from outside collaborators to internal laboratory and from internal PD efforts to cGMP manufacturing sites
+ Participate in selection, purchase, and implementation of laboratory equipment
+ Foster and leverage synergistic interactions with other sub-groups in Organ Manufacturing (e.g., Bioink, Scaffold Production, Cellularization), as needed
+ Author and contribute to scientific publications and present data at scientific conferences
+ Perform other duties as assigned
For this role you will need
Minimum Requirements
+ BIOPROCESS ENGINEER: 3+ years of relevant industry experience with prior experience in stem cell therapy, bioreactor cell production scale up, regenerative medicine, tissue engineering with a BA/BS Degree in biomedical science, cell biology or related field OR 1+ years of relevant industry experience in stem cell biology, bioreactor cell production scale up, regenerative medicine, tissue engineering with a Master's Degree in biomedical science, cell biology or related field
+ SR LEVEL: 5+ years of relevant industry experience with prior experience in stem cell therapy, bioreactor cell production scale up, regenerative medicine, tissue engineering with a BA/BS Degree in biomedical science, cell biology or related field OR 3+ years of relevant industry experience in stem cell biology, bioreactor cell production scale up, regenerative medicine, tissue engineering with a Master's Degree in biomedical science, cell biology or related field
+ Strong working knowledge of cellular process development
+ Experience with cell bioreactor culture.
+ Experience with automated cell processing equipment such CliniMACS Plus, LOVO, Cue, Sepax, Sefia, Rotea or others
+ Knowledge in transfer of R&D cell expansion methods to GMP
+ Facility with appropriate word processing, spreadsheet, presentation and related standard software; Experience with laboratory instrumentation and data software
+ Excellent written and oral communication skills
+ Strong organizational skills and attention to detail
+ Must be able to accommodate a non-traditional work schedule (e.g. Sun-Thu, Tue-Sat)
Preferred Qualifications
+ Master’s Degree in biomedical science, cell biology or related field
+ Sartorius Ambr/B-DCU systems and/or vertical wheel bioreactors with scales up to 10L+ preferred.
At United Therapeutics, you’ll realize quickly that it is not an ordinary place to work! When you join our company, you will learn, grow, contribute, have fun, and be challenged... all while making a difference in the lives of our patients.
_While United Therapeutics does not require vaccination for Covid-19 at this time, we strongly encourage all employees and visitors to remain up to date on vaccinations and boosters to protect one another from illness. Employees working in customer-facing roles must adhere and comply with customers’ credentialing guidelines, which may require vaccination against Covid -19, the influenza virus, and other illnesses that could be harmful to healthcare staff and patients._
United Therapeutics Corporation is an Equal Opportunity/Affirmative Action Employer - EOE Minorities / Females / Protected Veterans / Individuals with Disabilities
_We strive to be an organization that engages the minds, hearts, and most spirited efforts of each of our employees. Our sense of purpose transforms what we do from work into mission, occupation into vocation and achievement into success._
_We challenge our employees with innovative and revolutionary projects, offer an environment which fosters high-level job performance and provide a highly competitive total rewards package. This is what makes United Therapeutics a stimulating place to work._
Source : United Therapeutics