Associate Scientist, Downstream Process Development and Manufacturing at Dren Bio

Associate Scientist, Downstream Process Development and Manufacturing

About the Company:

Dren Bio (the "Company") is a privately held, clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company's management team and scientific advisors have profound expertise covering the discovery and development of specially engineered antibodies. Dren Bio's pipeline encompasses a multitude of programs from its two distinct, wholly-owned technologies. The Company's lead development candidate, DR-01, induces antibody-mediated killing of a specific cell type known to play a key role in various hematologic malignancies and autoimmune disorders. In addition to DR-01, the Company has launched multiple programs from its proprietary Targeted Myeloid Engager and Phagocytosis Platform, a bispecific antibody-based technology that offers a novel mechanism of action focused on selectively engaging myeloid cells (antigen presenting cells) for the targeted depletion of pathologic cells and other disease-causing agents.

Function:

Purification and Formulation Process Development and Manufacturing

Level:

Associate Scientist

Location:

Foster City, CA

Reporting Manager:

Director, Downstream Process Development

About the Opportunity:

Dren Bio is seeking a highly motivated Associate Scientist to become an integral member of the Downstream Process Development group. The Downstream Process Development group is responsible for critical drug development functions such as: development of robust downstream processes, technology transfer and scale-up to contract manufacturing facilities, and technical support and overseeing of manufacturing at contract manufacturing facilities. The scope of the position and requirements are described below.

Role and Responsibilities:

• Develop and scale-up robust multi-step purification processes

• Design and execute drug substance formulation studies

• Present experimental data in project and group meetings

• Author technical reports

• Implement new purification technologies to optimize and streamline processes

• Transfer and oversee purification process at CMO for GMP manufacturing

• Review executed batch records from CMO manufacturing

• Produce material for in-house development

Education, Experience and Qualification Requirements:

• Bachelors or Masters degree in Chemistry, Biochemistry or related scientific field.

• 4+ years of relevant industry experience for MS and 6+ years for BS level candidates.

Core Competencies, Knowledge and Skill Requirements:

• Experienced in protein purification techniques including column chromatography,standard membrane filtration and Ultrafiltration/Diafiltration

• Working knowledge of AKTA systems and Unicorn programming

• Ability to analyze and interpret complexed process data

• Work independently and proactively with minimal supervision

• Strong interpersonal skills and excellent oral and written communication skills

• Ability to travel and perform Person-in-Plant manufacturing oversight at a CMO ispreferred

• Experience working with external manufacturing vendors and partners is preferred

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. The base pay range for this position at commencement of employment is expected to be between $95,000 and $120,000 per year. At Dren Bio, pay ranges are determined by role, level(s), and location. The range displayed in this job posting reflects the minimum and maximum new hire pay for candidates located across all United States job markets. Within the range, individual pay will be determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, Dren Bio’s Human Resources department can share more about the specific pay range based on the market location of the candidate.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.