Associate Manager Statistical Genetics - Regeneron Pharmaceuticals, Inc.

We are looking for a researcher with a strong track-record in Statistical Genetics or Genetic Epidemiology, to join our Analytical Genomics team at the Regeneron Genetics Center. The role will involve hands on research and development, working across a variety of applications involving large scale genetic variation. This includes exome sequencing, GWAS and analyses of transcriptomics, proteomics and other omic datasets. In this role, you will connect genetic variation to human diseases and health outcomes, and then help translate genetic associations into new therapeutic opportunities for both common and rare diseases.

In this role, a typical day might include the following:

• Use RGC pipelines to perform GWAS and exome-wide association analyses using multiple cohorts totaling >2 million participants.

• Critically review and provide feedback on statistical methods and analyses plans, results and summaries to ensure they are accurate and reliable. Identify potential problems and propose remedies or refinements.

• Apply post-GWAS approaches (for example fine mapping, colocalization with other traits, Mendelian randomization) to identify likely effector genes of GWAS signals.

• Integrate association results from common variants from GWAS and rare variants from exome sequencing to identify novel gene associations with human diseases and traits.

• Perform polygenic risk score analyses.

This job might be for you if you:

• Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward within Regeneron.

• Have ability to work in a highly interactive environment with a diverse team of colleagues.

• Have outstanding communication skills to summarize and present new statistical methods and concepts and the results of human genetic studies to a variety of technical audiences, ranging from experts in statistical genetics and computation to experts in biology, drug design and medicine.

• Are a motivated teammate with a desire to pursue genetic discovery in a multi-disciplinary environment.

To be considered for this role, you must have a PhD in Statistical Genetics, Human Genetics, Genetic Epidemiology or a related field as well as postdoctoral experience with minimum 1-2 years of experience. A strong track record in these fields is required, evidenced by a strong publication record. Candidates will demonstrate experience using a range of statistical genetics tools, including for association analysis (e.g. PLINK, BOLT-LMM, REGENIE), fine mapping (e.g. FINEMAP, SUSIE), co-localization (e.g. COLOC, eCAVIAR) and Mendelian Randomization (e.g. SMR). The candidate should also be familiar with and follow best programming practices. Experience using cloud computing and trusted research environments is highly desired.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)