Associate Laboratory Manager - Cabaletta Bio Inc.

Philadelphia, PA

Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on the discovery and development of engineered T cell therapies that have the potential to provide a deep and durable, perhaps curative, treatment for patients with autoimmune diseases. The CABA™ platform encompasses two strategies: the CARTA (chimeric antigen receptor T cells for autoimmunity) strategy, with CABA-201, a 4-1BB-containing fully human CD19-CAR T, as the lead product candidate being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical trials in systemic lupus erythematosus, myositis, systemic sclerosis and generalized myasthenia gravis, and the CAART (chimeric autoantibody receptor T cells) strategy, with multiple clinical-stage candidates, including DSG3-CAART for mucosal pemphigus vulgaris and MuSK-CAART for MuSK myasthenia gravis. The expanding CABA™ platform is designed to develop potentially curative therapies that offer deep and durable responses for patients with a broad range of autoimmune diseases. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, visit www.cabalettabio.com and follow us on LinkedIn and X (Twitter).

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. 

We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great:  Working at Cabaletta Bio Inc | Great Place to Work®

About the Position

At Cabaletta we are applying our Cabaletta Approach to B cell Ablation (CABA) to develop T cell therapies to transform the lives of patients with autoimmune diseases. Reporting to the Head of Lab Operations, the Associate Laboratory Manager will support the operations, leadership, direction, and administration of our growing laboratory space, including a longer-term opportunity with new lab build out. The role will offer opportunities to work and cultivate skills within the cellular, molecular, and biochemical arenas, as well as inventory management and waste disposal/safety procedures.

Responsibilities:

• In conjunction with Lab Ops team, lead activities for cell line maintenance, culturing, and day to day passaging of cells.
• Daily upkeep of laboratory space, including but not limited to, cleaning and restocking of supplies, biological waste disposal, and preparation of media, buffers, and solutions.
  • Equipment monitoring including software dashboard, yearly calibration, and cleaning across multiple teams and lab spaces.
  • Compressed gas tank movement and change out. Must be capable of pushing 230-Liter LN2 tank on wheels.
• Support inventory management and purchasing activities by maintaining organizational oversight of laboratory supplies and restocking processes.
  • Including inputting items into inventory management and weekly checks.
  • Maintain variety of documentation across lab ops e.g. IOPQs, PMs, COA/COC, cleaning logs, calibrations
• Collaborate with broader research teams across Cellular Molecular Immunology, Preclinical Molecular Biology, and Process Development to support as needed.
• Monitor all lab spaces working with departments to ensure proper resources, safe working conditions/practices, and overall quality compliance.
• Assist in onboarding new lab personnel and overall lab space development or growth.
• Develop, implement, and maintain laboratory guidelines and standard operating procedures consistent with GXP requirements.
• Coordinate lab access with external personnel e.g. vendors, field service engineers, and building management.

Qualifications:

• Bachelor’s degree in a scientific discipline, including but not limited to biology, chemistry, and engineering.
• 1-2 years academic or industrial experience maintaining cell lines and performing mammalian cell culture.
• Experience preparing laboratory reagents for experimental use.
• Must be able to lift ~40lb onto a cart and ~10lb over your head.
• Foundational understanding of laboratory equipment.
• Strong attention to detail and organizational skills are required.
• Clear written and verbal communication skills and an ability to work independently.
• Proactive attitude and helpful mindset.
• Strong team orientation and passion for continuous self-development.

Preferred Qualifications:

• Experience with sample/inventory tracking and management.
• Experience with LIMS or ELN
• Foundational knowledge of GDP, GLP
• A high level of flexibility to support various other activities; the ability to learn new techniques outside of existing field of expertise.
• Zero to two plus years of lab operations experience within industrial or academic settings
• Experience with bacterial cell culture, molecular or biochemical assays (PCR, ELISA) and protein purification.

Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.

For more information, please visit  https://www.cabalettabio.com/join-our-crew

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.