Associate Director, Protein Biochemistry at Regeneron Pharmaceuticals, Inc.

The Protein Biochemistry Group is seeking a highly motivated Associate Director to lead molecular profiling, developability and characterization of therapeutic proteins, representing a variety of formats. In this exciting role, you will also provide matrix based support for the characterization of novel modalities such as gene therapy agents and oligonucleotides as well as complex therapeutic strategies and approaches.

A Typical Day in the Role of Associate Director Might Look Like:

• Participates in and oversees protein or new modality characterization to provide molecular profiles and developability assessments of therapeutic assests, that support the pipeline, in a timely manner and aligned with partner functions.
• Understand current computational biophysics approaches (workflows, software) for building static and dynamic models (in silico profiles) that compliment experimentally derived molecular data.
• Reviews the literature and works with their team to design experiments that solve biophysical problems for key stakeholders.
• Supervises and supports scientists with critical data review as well as career development. Builds an effective molecular characterization team.
• Ability and enthusiasm for independently learning new methods and softwares. Is a go-to resource for explaining and solving biophysical problems.
• Practical knowledge of downstream purification, analytical method and formulation development of biologics and drug product profiles aligned with therapeutic strategies.

This Role Might Be For You If You:

• Have in-depth knowledge of macromolecular physical chemistry especially solution interactions and hands-on experience in protein characterization using a variety of analytical tools
• Have established computational and molecular modeling experience to compliment in silico - derived information with experimental data
• Are an effective communicator of ideas, project goals and results to team members within the group and with colleagues in collaborating departments
• Can proactively identify issues and develop solutions in a collaborative multidisciplinary environment

This role requires a PhD in pharmaceutical sciences, biophysics, biochemistry, chemical engineering or equivalent with at least 9 years post-doctoral training combined with industry experience in characterization of therapeutic protein candidates. Extensive experience with computational biophysics and molecular static and dynamic modeling. Practical experience with standard modeling softwares such as (but not limited to) Schrodinger (or MOE), Discovery Studio, Gromacs, Gaussian etc. Knowledge of and demonstrated expertise with light scattering, liquid chromatography, and capillary electrophoresis instrumentation is essential. Experience in spectroscopic (e.g. CD, fluorescence, and/or FTIR) principles and applications for analysis of proteins, size-based (AUC, LC, MALS) and charge-based (e.g. icIEF, IEX) separation techniques is important. Mass spec experience a plus. Experience of developing and troubleshooting analytical methods and must demonstrate the ability to plan, design, implement laboratory experimentation to advance projects. as well as experience with statistical and experimental design, molecular modeling, graphing and mathematical analysis softwares is also important.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$170,100.00 - $277,500.00