Senior Scientist, Analytical Chemist - JLSa2 Therapeutics, Inc

JLSa2 is a new and recently launched seed-stage venture backed company, located in South San Francisco, focused upon developing novel multifunctional protein-drug conjugate therapies to address human metabolic diseases and other non-oncology related diseases. 

The company is seeking a Senior Scientist to lead the analytical activities of characterizing biophysical properties of these multifunctional conjugates as well as contribute to multiple aspects of product development as molecules progress from research stage to early clinical development. 

Responsibilities:

The candidate will lead characterization efforts of proteins, peptides, and other synthetic conjugates, including any changes after exposure to biological matrices, primarily using mass spectrometry and HPLC assays.  The candidate will work in a highly collaborative team with the conjugation and biology teams, as well as senior leadership, to ensure data integration across functional areas to ensure rapid decision making and product iteration cycle time.  This position will supervise junior scientists and is expected to be on site at our SSF facility. 

Qualifications:

PhD in analytical chemistry, biochemistry, or related scientific field and 5+ years of industry experience in the characterization of biologic conjugates or peptides is required OR

BS/MS in analytical chemistry, biochemistry, or related scientific field and 12+/8+ years of industry experience in the characterization of biologic conjugates or peptides is required

Requires a strong background in mass spectrometry of proteins, and liquid chromatography assays such as RP-HPLC, SEC, CEX, HIC.   Experience in capillary electrophoresis, SDS-PAGE, plate based assays, and high throughput sample management is preferred.  Experience with standard conjugation chemistries is a plus. 

Demonstrated proficiency in both hands-on analytical work and management activities, and experience reviewing, organizing, and presenting analytical data.

Demonstrated leadership ability, including a commitment to mentorship and development of personnel. 

Flexibility to work on multiple projects in a fast-paced start up environment is essential.

Good communication skills are essential.

Salary Range: $150,000 - $175,000 (Compensation and level will be commensurate with experience and expertise and could fall outside of the stated range)

Competitive benefits package is offered that includes health, dental, and vision insurance, life insurance, 401K plan, non-accruing PTO, and early-stage equity.