Senior Research Associate, Formulation and Analytical Chemistry - Entrada Therapeutics

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45 and 50 skipping amenable. We have also partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are a highly motivated Senior Research Associate who thrives in a collaborative and fast-paced environment. The ideal candidate is detail-oriented and interested in working at the intersection of our Formulation and Analytical Development teams.

The Opportunity

In this role, you will be responsible for the formulation of drug substances and the operation of multiple instruments including HPLC, LC-MS, and UV-Vis. You will formulate and characterize the formulation of oligonucleotides, peptides, conjugates, and other novel molecules. You will also manage the chemical inventory, ordering chemicals and supplies, and maintaining a good experimental record will be a key part of your role. You are expected to interpret and present research data and findings in internal scientific meetings as well as prepare procedures and technical reports.

Responsibilities

• Lead oligonucleotide/peptide/conjugates formulation for in vitro and in vivo studies to support all discovery projects.
• Analyze formulation samples using various instruments such as LCMS and HPLC.
• Coordinate with neuromuscular and discovery biology teams for data and sample transfers.
• Organize and document all experimental data and connect with all related in vitro and in vivo
• Contribute to reports and presentations. During internal and external meetings, you should be ready to interpret and present research data and findings. 

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• BS (4+ years relevant experience) or MS degree (2+ years relevant experience) in Pharmaceutical Sciences, Chemistry, Biology, Bioengineering, or a related field.
• Hands-on experience of oligonucleotide/peptide/conjugates formulation for in vitro and in vivo biological assays is required.
• Ability to execute pipetting tasks accurately and efficiently to maintain the integrity of experimental results.
• Hands-on experience with analytical instrumentation such as UV-Vis, IEX-HPLC, RP-HPLC, LCMS for formulation characterization is required.
• An understanding of laboratory safety and best practice is required.
• Experience with aseptic handling techniques is preferred.
• Attention to detail and the ability to thoroughly document experimental work in electronic lab notebooks (ELNs).
• Understanding of oligonucleotide/peptide chemistry as well as the knowledge of analytical chemistry is a plus.
• Excellent written skills to author SOPs and technical reports, and verbal communication skills to present internally and externally.
• To be effective on our team, you must have the ability to interact effectively in a multi-disciplinary, fast-paced research environment as well as the ability to multi‐task to meet research and development goals.

The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

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