Research Associate/ Senior Research Associate, Oncology Research - Dren Bio

Research Associate/ Senior Research Associate, Oncology Research

About the Company:

Dren Bio (the "Company") is a privately held, clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company's management team and scientific advisors have profound expertise covering the discovery and development of specially engineered antibodies. Dren Bio's pipeline encompasses a multitude of programs from its two distinct, wholly-owned technologies. The Company's lead development candidate, DR-01, induces antibody-mediated killing of a specific cell type known to play a key role in various hematologic malignancies and autoimmune disorders. In addition to DR-01, the Company has launched multiple programs from its proprietary Targeted Myeloid Engager and Phagocytosis Platform, a bispecific antibody-based technology that offers a novel mechanism of action focused on selectively engaging myeloid cells (antigen presenting cells) for the targeted depletion of pathologic cells and other disease-causing agents.

Function:

Oncology

Level:

Research Associate II/Senior Research Associate

Location:

Foster City, CA

Reporting Manager:

Scientist II, Oncology

About the Opportunity:

Dren Bio is seeking a bright and highly motivated and experienced research associate to support our targeted myeloid engager bispecific platform for the treatment of solid cancer indications. The ideal candidate has extensive experience in a wide variety of techniques in the fields of immunology and cell and molecular biology. Strongest consideration will be given to candidates with strong technical experience with myeloid cell biology and background in the fields of cancer immunology. The candidate will work with a cross-functional team of scientists (immunologists, cell biologists, biochemists, and protein engineers) to advance research stage programs into early clinical development. The candidate is expected to execute and report in vitro and ex vivo studies and be flexible in a fast-paced environment.

Role and Responsibilities:

• Isolate primary cells, including immune cells, from murine and human blood andtissues

• Maintain cell lines or differentiate primary myeloid cells to different lineages

• Design flow cytometric analysis panels and perform subsequent analyses on human andmurine immune and/or tumor cells

• Perform ADCC, ADCP, and other cell-based assays

• Conduct biochemical assays and bead-based immunoassays (Western blot, ELISA, MSD,Luminex etc)

• Adhere strictly to SOPs for non-clinical and clinical sample processing and flowcytometry analysis

• Process, analyze and present data in project meetings

• Work collaboratively with other researchers to advance various therapeutic antibodiesin different types of cancer and autoimmune indications

• Keep detailed records of protocols and workflow

Education, Experience and Qualification Requirements:

• BS degree in cell biology, immunology or related field, and 2+ years of experience inacademia or biopharmaceutical industry.

Core Competencies, Knowledge and Skill Requirements:

• Broad knowledge of immunology and good technical expertise in cellular and molecularimmunology

• Routine literature search and communication with technical support to optimize andestablish new techniques

• 1+ years of multi-color flow cytometry

• Knowledge of sterile tissue culture techniques

• Experience with tissue processing, primary cell isolation and culture

• Experience with plate-based ELISAs, electrochemiluminescence (ECL)- based (e.g., MSDplatform) and/or bead-based (e.g., Luminex multiplex platform) immunoassays

• Data processing and analysis software (Flowjo, GraphPad Prism, ImageJ)

• Excellent oral/written communication skills

• Highly motivated and willing to adapt and learn new techniques to support drugdevelopment efforts

• Engage to work collaboratively within teams to deliver exceptional results

• Must be well organized, diligent, and willing to adapt to a fast-paced researchenvironment

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. The base pay range for this position at commencement of employment is expected to be between $78,000 and $104,000 per year. At Dren Bio, pay ranges are determined by role, level(s), and location. The range displayed in this job posting reflects the minimum and maximum new hire pay for candidates located across all United States job markets. Within the range, individual pay will be determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, Dren Bio’s Human Resources department can share more about the specific pay range based on the market location of the candidate.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.