Protein Biochemist/ Engineer - Battelle Memorial Institute
Columbus, OH
About the Job
Battelle delivers when others can’t. We conduct research and development, manage national laboratories, design and manufacture products and deliver critical services for our clients—whether they are a multi-national corporation, a small start-up or a government agency.
We recognize and appreciate the value and contributions of individuals with diverse backgrounds and experiences and welcome all qualified individuals to apply.
Job Summary
Battelle is guided by a founding mission. We invest our knowledge, talents and resources, helping our customers achieve their most important goals. We apply scientific rigor and creativity, succeeding where others may fail, and we invest in our communities, making the world better for generations to come. All of us share a common purpose: to solve the greatest challenges of today and tomorrow.
Our 22,000 employees work at the forefront of scientific innovation to tackle critical challenges in security, human health, manufacturing, energy, and environmental management. Battelle’s work is grounded in the belief that science, technology, and a passion for excellence can make industries more competitive and the world a better place.
Battelle is currently seeking a highly skilled and motivated Protein Biochemist/Engineer for the National Security Business Unit. This full-time position is located in Columbus, Ohio . Some domestic and international travel is anticipated.
PRIMARY FUNCTION
As a Computational Biologist/Protein Engineer, you will play a pivotal role in conducting cutting-edge research by leveraging your expertise in computational biology, systems biology, metabolic modeling, protein modeling, protein design, and using other bioinformatics tools. The successful candidate will demonstrate technical leadership and provide invaluable support in modeling and predicting natural and synthetic regulatory networks, using machine learning based protein engineering tools, predicting protein-ligand binding, and leveraging other state-of-the-art protein modeling and protein engineering tools. The candidate should have proficiency with programming languages such as Python and R, bioinformatics tools, systems biology modeling packages, metabolic modeling packages such as COBRA-Py, protein modeling tools such as Alphafold3, MPNN, and others. Additionally, you will actively identify and capitalize on opportunities to lead projects that enhance capabilities and foster the development of novel technical approaches. This position offers an opportunity to collaborate with a dynamic, multidisciplinary team committed to advancing scientific knowledge and generating significant contributions to the field of protein biochemistry.
Responsibilities
+ Modeling of native and _de novo_ designed proteins to understand small molecule and protein-protein binding in a larger protein development pipeline.
+ Work independently to meet study or campaign objectives and meet deliverables with some oversight.
+ Conduct and manage protein expression, purification, and characterization using a range of methodologies including chromatography, and electrophoresis.
+ Develop and optimize high throughput protein purification protocols and methodologies for improved yield and quality.
+ Analyze and interpret experimental data, and contribute to the preparation of technical reports, scientific manuscripts, and presentations.
+ Train and mentor junior technical staff.
+ Some domestic and potential international travel is anticipated.Follows written/documented quality, process, and safety procedures to meet precise standards and strict tolerances.
+ Accurately documents process parameters and data. Maintains data in manufacturing and nonconformance databases.
+ Contributes to the technical planning of project work including recommending, testing, and implementing improved methods.
+ Identifies and documents process issues and participates in problem solving efforts/root cause analysis.
+ Contributes to equipment maintenance, troubleshooting, and repair tasks.
+ Performs area housekeeping tasks.
Key Qualifications
↵
+ PhD and 0-4+ years of experience in biochemistry or a related field.
+ Experience in artificial intelligence and machine learning approaches for de novo protein design.
+ Experience with tools designing and optimizing protein-ligand and protein-protein interactions.
+ Experience/proven ability to script and code using R, Python, and/or Bash/Unix shell.
+ Excellent problem-solving skills, critical thinking abilities, and attention to detail.
+ Strong communication and interpersonal skills, with the ability to work collaboratively in a team-oriented environment.
+ Ability to travel.
+ Sufficiently medically fit to work in the laboratory and in the field to perform assigned duties.
+ U.S. citizenship, with the ability to obtain and maintain required government security clearances as a condition of employment.
Preferred Qualifications
+ Experience working within laboratory quality management systems (e.g., ISO 9001, ISO17025, GLP).
+ Experience with high-throughput automation equipment or directed evolution.
+ Expertise in protein purification techniques such as affinity chromatography, size exclusion chromatography, and ion exchange chromatography using chromatography systems such as AKTA or NGC.
+ Proficiency in protein characterization techniques including SDS-PAGE and/or Western blotting.
+ Expertise in protein expression systems (e.g., _E. coli_ , yeast, mammalian cells) and recombinant protein production.
Benefits: Live an Extraordinary Life
We care about your well-being, not just on the job. Battelle offers comprehensive and competitive benefits to help you live your best life.
+ Balance life through a compressed work schedule : Most of our team follows a flexible, compressed work schedule that allows for every other Friday off—giving you a dedicated day to accomplish things in your personal life without using vacation time.
+ Enjoy enhanced work flexibility, including a hybrid arrangement: You have options for where and when you work. Our Together with Flexibility model allows you to work 60% in-office and 40% remote, with Monday and Tuesday as common in-office days, dependent on team and position needs.
+ Take time to recharge : You get paid time off to support work-life balance and keep motivated.
+ Prioritize wellness : Stay healthy with medical, dental, and vision coverage with wellness incentives and benefits plus a variety of optional supplemental benefits.
+ Better together : Coverage for partners, gender-affirming care and health support, and family formation support.
+ Build your financial future : Build financial stability with an industry-leading 401(k) retirement savings plan. For most employees, we put in 5 percent whether you contribute or not, and match your contributions on top of that.
+ Advance your education : Tuition assistance is available to pursue higher education.
+ Flexible work arrangements : You have options for where you work and when you work.
A Work Environment Where You Succeed
For brilliant minds in science, technology, engineering and business operations, Battelle is the place to do the greatest good by solving humanity’s most pressing challenges and creating a safer, healthier and more secure world.
You will have the opportunity to thrive in a culture that inspires you to:
+ Apply your talent to challenging and meaningful projects
+ Receive select funding to pursue ideas in scientific and technological discovery
+ Collaborate with world-class experts in an inclusive environment
+ Nurture and develop the next generation of scientific leaders
+ Give back to and improve our communities
Vaccinations & Safety Protocols
_Battelle may require employees, based on job duties, work location, and/or its clients’ requirements to follow certain safety protocols and to be vaccinated against a variety of viruses, bacteria, and diseases as a condition of employment and continued employment and to provide documentation that they are fully vaccinated. If applicable, Battelle will provide reasonable accommodations based on a qualified disability or medical condition through the Americans with Disabilities Act or the Rehabilitation Act or for a sincerely held religious belief under Title VII of the Civil Rights Act of 1964 (and related state laws)._
_Battelle is an equal opportunity employer. We provide employment and opportunities for advancement, compensation, training, and growth according to individual merit, without regard to race, color, religion, sex (including pregnancy), national origin, sexual orientation, gender identity or expression, marital status, age, genetic information, disability, veteran-status veteran or military status, or any other characteristic protected under applicable Federal, state, or local law. Our goal is for each staff member to have the opportunity to grow to the limits of their abilities and to achieve personal and organizational objectives. We will support positive programs for equal treatment of all staff and full utilization of all qualified employees at all levels within Battelle._
The above statements are intended to describe the nature and level of work being performed by people assigned to this job. They are not intended to be an exhaustive list of all responsibilities, activities and skills required of staff members. No statement herein is intended to imply any authorities to commit Battelle unless special written permission is granted by Battelle's Legal Department.
For more information about our other openings, please visit www.battelle.org/careers
We recognize and appreciate the value and contributions of individuals with diverse backgrounds and experiences and welcome all qualified individuals to apply.
Job Summary
Battelle is guided by a founding mission. We invest our knowledge, talents and resources, helping our customers achieve their most important goals. We apply scientific rigor and creativity, succeeding where others may fail, and we invest in our communities, making the world better for generations to come. All of us share a common purpose: to solve the greatest challenges of today and tomorrow.
Our 22,000 employees work at the forefront of scientific innovation to tackle critical challenges in security, human health, manufacturing, energy, and environmental management. Battelle’s work is grounded in the belief that science, technology, and a passion for excellence can make industries more competitive and the world a better place.
Battelle is currently seeking a highly skilled and motivated Protein Biochemist/Engineer for the National Security Business Unit. This full-time position is located in Columbus, Ohio . Some domestic and international travel is anticipated.
PRIMARY FUNCTION
As a Computational Biologist/Protein Engineer, you will play a pivotal role in conducting cutting-edge research by leveraging your expertise in computational biology, systems biology, metabolic modeling, protein modeling, protein design, and using other bioinformatics tools. The successful candidate will demonstrate technical leadership and provide invaluable support in modeling and predicting natural and synthetic regulatory networks, using machine learning based protein engineering tools, predicting protein-ligand binding, and leveraging other state-of-the-art protein modeling and protein engineering tools. The candidate should have proficiency with programming languages such as Python and R, bioinformatics tools, systems biology modeling packages, metabolic modeling packages such as COBRA-Py, protein modeling tools such as Alphafold3, MPNN, and others. Additionally, you will actively identify and capitalize on opportunities to lead projects that enhance capabilities and foster the development of novel technical approaches. This position offers an opportunity to collaborate with a dynamic, multidisciplinary team committed to advancing scientific knowledge and generating significant contributions to the field of protein biochemistry.
Responsibilities
+ Modeling of native and _de novo_ designed proteins to understand small molecule and protein-protein binding in a larger protein development pipeline.
+ Work independently to meet study or campaign objectives and meet deliverables with some oversight.
+ Conduct and manage protein expression, purification, and characterization using a range of methodologies including chromatography, and electrophoresis.
+ Develop and optimize high throughput protein purification protocols and methodologies for improved yield and quality.
+ Analyze and interpret experimental data, and contribute to the preparation of technical reports, scientific manuscripts, and presentations.
+ Train and mentor junior technical staff.
+ Some domestic and potential international travel is anticipated.Follows written/documented quality, process, and safety procedures to meet precise standards and strict tolerances.
+ Accurately documents process parameters and data. Maintains data in manufacturing and nonconformance databases.
+ Contributes to the technical planning of project work including recommending, testing, and implementing improved methods.
+ Identifies and documents process issues and participates in problem solving efforts/root cause analysis.
+ Contributes to equipment maintenance, troubleshooting, and repair tasks.
+ Performs area housekeeping tasks.
Key Qualifications
↵
+ PhD and 0-4+ years of experience in biochemistry or a related field.
+ Experience in artificial intelligence and machine learning approaches for de novo protein design.
+ Experience with tools designing and optimizing protein-ligand and protein-protein interactions.
+ Experience/proven ability to script and code using R, Python, and/or Bash/Unix shell.
+ Excellent problem-solving skills, critical thinking abilities, and attention to detail.
+ Strong communication and interpersonal skills, with the ability to work collaboratively in a team-oriented environment.
+ Ability to travel.
+ Sufficiently medically fit to work in the laboratory and in the field to perform assigned duties.
+ U.S. citizenship, with the ability to obtain and maintain required government security clearances as a condition of employment.
Preferred Qualifications
+ Experience working within laboratory quality management systems (e.g., ISO 9001, ISO17025, GLP).
+ Experience with high-throughput automation equipment or directed evolution.
+ Expertise in protein purification techniques such as affinity chromatography, size exclusion chromatography, and ion exchange chromatography using chromatography systems such as AKTA or NGC.
+ Proficiency in protein characterization techniques including SDS-PAGE and/or Western blotting.
+ Expertise in protein expression systems (e.g., _E. coli_ , yeast, mammalian cells) and recombinant protein production.
Benefits: Live an Extraordinary Life
We care about your well-being, not just on the job. Battelle offers comprehensive and competitive benefits to help you live your best life.
+ Balance life through a compressed work schedule : Most of our team follows a flexible, compressed work schedule that allows for every other Friday off—giving you a dedicated day to accomplish things in your personal life without using vacation time.
+ Enjoy enhanced work flexibility, including a hybrid arrangement: You have options for where and when you work. Our Together with Flexibility model allows you to work 60% in-office and 40% remote, with Monday and Tuesday as common in-office days, dependent on team and position needs.
+ Take time to recharge : You get paid time off to support work-life balance and keep motivated.
+ Prioritize wellness : Stay healthy with medical, dental, and vision coverage with wellness incentives and benefits plus a variety of optional supplemental benefits.
+ Better together : Coverage for partners, gender-affirming care and health support, and family formation support.
+ Build your financial future : Build financial stability with an industry-leading 401(k) retirement savings plan. For most employees, we put in 5 percent whether you contribute or not, and match your contributions on top of that.
+ Advance your education : Tuition assistance is available to pursue higher education.
+ Flexible work arrangements : You have options for where you work and when you work.
A Work Environment Where You Succeed
For brilliant minds in science, technology, engineering and business operations, Battelle is the place to do the greatest good by solving humanity’s most pressing challenges and creating a safer, healthier and more secure world.
You will have the opportunity to thrive in a culture that inspires you to:
+ Apply your talent to challenging and meaningful projects
+ Receive select funding to pursue ideas in scientific and technological discovery
+ Collaborate with world-class experts in an inclusive environment
+ Nurture and develop the next generation of scientific leaders
+ Give back to and improve our communities
Vaccinations & Safety Protocols
_Battelle may require employees, based on job duties, work location, and/or its clients’ requirements to follow certain safety protocols and to be vaccinated against a variety of viruses, bacteria, and diseases as a condition of employment and continued employment and to provide documentation that they are fully vaccinated. If applicable, Battelle will provide reasonable accommodations based on a qualified disability or medical condition through the Americans with Disabilities Act or the Rehabilitation Act or for a sincerely held religious belief under Title VII of the Civil Rights Act of 1964 (and related state laws)._
_Battelle is an equal opportunity employer. We provide employment and opportunities for advancement, compensation, training, and growth according to individual merit, without regard to race, color, religion, sex (including pregnancy), national origin, sexual orientation, gender identity or expression, marital status, age, genetic information, disability, veteran-status veteran or military status, or any other characteristic protected under applicable Federal, state, or local law. Our goal is for each staff member to have the opportunity to grow to the limits of their abilities and to achieve personal and organizational objectives. We will support positive programs for equal treatment of all staff and full utilization of all qualified employees at all levels within Battelle._
The above statements are intended to describe the nature and level of work being performed by people assigned to this job. They are not intended to be an exhaustive list of all responsibilities, activities and skills required of staff members. No statement herein is intended to imply any authorities to commit Battelle unless special written permission is granted by Battelle's Legal Department.
For more information about our other openings, please visit www.battelle.org/careers
Source : Battelle Memorial Institute