Process Development Scientist - Oligonucleotide Chemistry - Eurofins PSS Insourcing Solutions, LLC

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate.

Eurofins is the global leader in food, environment, pharmaceutical and cosmetic product testing and in agroscience Contract Research Organisation services. Eurofins is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organisations. The Group also has a rapidly developing presence in highly specialised and molecular clinical diagnostic testing and in-vitro diagnostic products.

In over just 30 years, Eurofins has grown from one laboratory in Nantes, France to 55,000 staff across a decentralised and entrepreneurial network of 900 laboratories in over 50 countries. Eurofins offers a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.

This is an exciting time to join the Eurofins Genomics LLC process development group. The company is rapidly expanding oligonucleotide manufacturing to support the increasing demand of molecular diagnostics. Process Development Scientist will work directly with some of the biggest companies in life sciences to manufacture and develop oligonucleotides (oligos) and support ever evolving needs. Eurofins Genomics LLC is a leading manufacturer of Oligonucleotide primers/probes/assays in addition to being a key supplier of oligos for other diagnostic applications.

The Process Development Scientist will be an owner in area of expertise (oligonucleotide synthesis, purification, organic chemistry, and quality control). This position reports directly to the Director of Oligonucleotide Chemistry

• Hands-on expertise in preparing chromatography and analytical techniques throughout the product development lifecycle, from early research to on-market support diagnostics
• Demonstrated experience purifying, analyzing, and characterizing complex oligonucleotides and related analytical methods.
• Ability to develop innovative analytical methods for reagents and assay performance, applicable in R&D and Operations; supporting scale-up and launch efforts
• Ability to design and execute advanced troubleshooting experiments in coordination with collaborators; demonstrated experience developing creative assays to understand and detect system defects
• Ability to support documentation transfer, specifically of prototype methods and documentation from research to development and manufacturing
• Serve as a subject matter expert and provide expertise across R&D departments (oligo synthesis & purification, assay development) and operations
• Document all assays and results in a standardized, accurate, traceable, and timely manner
• Perform mentor type duties including the training of more junior employees
• Adhering to cGMP/cGLP documentation procedures according to FDA specifications
• HPLC method development for specific DNA/RNA modifications, scales, lengths, and purity
• Customization of method and mobile phases to maximize yields while maintaining quality
• Develop new downstream workflows for automated larger scale purification process
• Develop and implement other purification processes (PAGE, Cartridge, etc) that expand portfolio for purification

• BS + minimum 5 years/MS/PhD in Chemistry, Biochemistry, or a related field
• Manufacturing experience and comfortability being in a production role
• Work with nucleic acids
• Experience with oligonucleotide synthesis
• A positive attitude, strong work ethic, and ability to work both independently and in constructive groups

Schedule:

• Monday-Friday 8:00am-5:00pm

What we offer:

• Excellent full time benefits including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays

Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.