2025 U.S Summer Internship Program: Metabolite Identification/Synthesis Intern at Takeda

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Job Description

The Biotransformation function is a part of Takeda’s Absorption Distribution Metabolism Excretion (ADME) team. This team investigates how a drug is converted into metabolites, what metabolites are produced from a drug, and elimination pathway of a drug in animals and humans. The data generated informs major human metabolites for safety, efficacy, and drug-drug interaction assessment.

The intern will:

• Generate an uncommon metabolite of an FDA approved drug in in vitro systems
• Support efforts through which the metabolite will be isolated by HPLC and subject to NMR characterization. The metabolite structure will be elucidated using the LC-MS and NMR data. The formation mechanism of the metabolite will be proposed based on the structure.
• Identify the enzyme contributing to the formation of the metabolite. The findings will eventually be written as a scientific manuscript for publication.

Internship Development Opportunities:

The intern will learn how the drug metabolite is generated in the lab. The intern will also learn to use modern analytical techniques including state-of-the-art LC-HRMS and NMR to characterize a metabolite and perform reaction phenotyping of the metabolite generation.

Job Requirements:

• This position will be Fully Onsite and require 4+ days in the Cambridge office per week.
• Must be a Graduate student pursuing their Ph.D. degree in drug metabolism, chemistry, biochemistry, or life science field
• Hands-on experience on HPLC analysis is required.
• Experience on qualitative analysis/structure elucidation for small molecules using LC-HRMS and NMR is preferred.
• Experience with microsomal incubation is preferred.
• The candidate should have strong organic knowledge background.
• Basic understanding of computer skills including MS Office (PowerPoint, Words, Excel)
• Internet skills including use of e-mails, group messaging and information gathering
• Highly reliable and a strong team player
• Flexible with an attention to detail
• Strong verbal and written communication skills

Internship Eligibility

• Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship
• Must be currently enrolled in a degree program graduating December 2025 or later
• The internship program is 10-12 weeks depending on the two start dates (June 2nd- August 22nd) or (June 16th - August 29th)
  • The intern must be able to commit to one of these time frames
• Able to work full time 40 hours a week during internship dates
• Takeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program

Program Highlights:

• Hands-on experience with real projects and responsibilities
• Dedicated mentorship program pairing interns with experienced professionals
• Networking opportunities with industry professionals and fellow interns
• Internship events focused on professional and skills development
• Exposure to multiple business areas or departments within a Pharmaceutical Organization

Applications will be accepted between January 6th and January 31st

Takeda Compensation and Benefits Summary

We understand compensation may bean important factor as you consider an internship opportunity. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

U.S. Hourly Wage Range:

$21.00 - $46.00

The estimated hourly range reflects an anticipated range for this position. The actual hourly wage offered will depend on the candidate’s school year/level to be entered following completion of internship.The actual hourly wage offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. internship benefits vary by location and may include:

• Paid sick time

• Civic Duty paid time off

• Participation at company volunteer events

• Participation at company sponsored special events

• Access to on-site fitness center (where available)

• Commuter Benefit: To offset your work-commute expenses, Takeda provides U.S. employees with a fixed monthly subsidy to be used for either public transportation (transit) or parking.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypePaid Intern (Fixed Term) (Trainee)

Time TypeFull time

Job Exempt